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LTO1_SCHPO
ID   LTO1_SCHPO              Reviewed;         134 AA.
AC   Q9Y7Q1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=LTO1 family protein C191.08 {ECO:0000305};
GN   ORFNames=SPCC191.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: The complex LTO1:YAE1 may function as a target specific
CC       adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur
CC       protein assembly (CIA) complex machinery. May be required for
CC       biogenesis of the large ribosomal subunit and initiation of
CC       translation. {ECO:0000250|UniProtKB:Q8WV07}.
CC   -!- SUBUNIT: May form a complex with YAE1. {ECO:0000250|UniProtKB:Q8WV07}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the LTO1 family. {ECO:0000305}.
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DR   EMBL; CU329672; CAB41054.1; -; Genomic_DNA.
DR   PIR; T41221; T41221.
DR   RefSeq; NP_588297.1; NM_001023287.2.
DR   AlphaFoldDB; Q9Y7Q1; -.
DR   SMR; Q9Y7Q1; -.
DR   BioGRID; 275774; 2.
DR   STRING; 4896.SPCC191.08.1; -.
DR   MaxQB; Q9Y7Q1; -.
DR   PaxDb; Q9Y7Q1; -.
DR   EnsemblFungi; SPCC191.08.1; SPCC191.08.1:pep; SPCC191.08.
DR   GeneID; 2539204; -.
DR   KEGG; spo:SPCC191.08; -.
DR   PomBase; SPCC191.08; -.
DR   VEuPathDB; FungiDB:SPCC191.08; -.
DR   eggNOG; KOG4595; Eukaryota.
DR   HOGENOM; CLU_1897425_0_0_1; -.
DR   InParanoid; Q9Y7Q1; -.
DR   OMA; WNRITAK; -.
DR   PhylomeDB; Q9Y7Q1; -.
DR   PRO; PR:Q9Y7Q1; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; ISS:UniProtKB.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; ISS:UniProtKB.
DR   InterPro; IPR019191; Essential_protein_Yae1_N.
DR   Pfam; PF09811; Yae1_N; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..134
FT                   /note="LTO1 family protein C191.08"
FT                   /id="PRO_0000337685"
FT   REGION          17..53
FT                   /note="deca-GX3 motif; required for interaction with YAE1
FT                   and the CIA complex"
FT                   /evidence="ECO:0000250|UniProtKB:P53846"
SQ   SEQUENCE   134 AA;  15485 MW;  D3CE4F6135531AF0 CRC64;
     MDWEEVTKLE ENEYKRGYDE GILKGIEQGY EEAFLFGLEH AYNKYLLAGE IYGRVCFWLK
     EENSQHPKIK KAHRHLEQLK SLLESLPTNN ELEETDAGFD SYWNKITAKA KVVSSLLGTK
     ILPAEKIDAN DGFE
 
 
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