ID   LTOR2_SALSA             Reviewed;         125 AA.
AC   B5X7X4;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Ragulator complex protein LAMTOR2;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2;
GN   Name=lamtor2;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Lysosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR   EMBL; BT047143; ACI66944.1; -; mRNA.
DR   EMBL; BT047817; ACI67618.1; -; mRNA.
DR   EMBL; BT047883; ACI67684.1; -; mRNA.
DR   EMBL; BT048025; ACI67826.1; -; mRNA.
DR   EMBL; BT049008; ACI68809.1; -; mRNA.
DR   EMBL; BT049017; ACI68818.1; -; mRNA.
DR   RefSeq; XP_014017422.1; XM_014161947.1.
DR   RefSeq; XP_014056261.1; XM_014200786.1.
DR   AlphaFoldDB; B5X7X4; -.
DR   SMR; B5X7X4; -.
DR   STRING; 8030.ENSSSAP00000017241; -.
DR   GeneID; 106580651; -.
DR   GeneID; 106605307; -.
DR   KEGG; sasa:106580651; -.
DR   KEGG; sasa:106605307; -.
DR   OMA; WAAYEKN; -.
DR   OrthoDB; 1515483at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa02.
DR   Proteomes; UP000087266; Chromosome ssa05.
DR   Bgee; ENSSSAG00000008231; Expressed in zone of skin and 16 other tissues.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0001558; P:regulation of cell growth; ISS:UniProtKB.
DR   InterPro; IPR037587; LAMTOR2-like.
DR   InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR   PANTHER; PTHR13323; PTHR13323; 1.
DR   Pfam; PF03259; Robl_LC7; 1.
DR   SMART; SM00960; Robl_LC7; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Ragulator complex protein LAMTOR2"
FT                   /id="PRO_0000365941"
FT   REGION          57..70
FT                   /note="Required for location at endosomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13549 MW;  7C944C795536C353 CRC64;
     MLRPKALTQV LSQANTSGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWSAYDKNG
     HQAFNEDKLK FILMDCMEGR VAITRVANLL LCMYAKETVG FGMLKAKAEA LVLYLEEPLT
     QVAAS