LTOR3_DANRE
ID LTOR3_DANRE Reviewed; 124 AA.
AC Q503S6;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Ragulator complex protein LAMTOR3;
DE AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
DE AltName: Full=Mitogen-activated protein kinase scaffold protein 1;
GN Name=lamtor3; Synonyms=mapksp1; ORFNames=zgc:110207;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC promotes cell growth in response to growth factors, energy levels, and
CC amino acids. As part of the Ragulator complex, may activate the TOR
CC signaling cascade in response to amino acids. Adapter protein that may
CC regulate the MAP kinase cascade. {ECO:0000250|UniProtKB:Q9UHA4}.
CC -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC slc38a9; the probable amino acid sensor. Component of the lysosomal
CC folliculin complex (LFC). {ECO:0000250|UniProtKB:O88653,
CC ECO:0000250|UniProtKB:Q9UHA4}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC095201; AAH95201.1; -; mRNA.
DR RefSeq; NP_001018410.1; NM_001020574.1.
DR AlphaFoldDB; Q503S6; -.
DR SMR; Q503S6; -.
DR STRING; 7955.ENSDARP00000116826; -.
DR PaxDb; Q503S6; -.
DR PeptideAtlas; Q503S6; -.
DR GeneID; 553597; -.
DR KEGG; dre:553597; -.
DR CTD; 8649; -.
DR ZFIN; ZDB-GENE-050522-345; lamtor3.
DR eggNOG; ENOG502RYGZ; Eukaryota.
DR InParanoid; Q503S6; -.
DR Reactome; R-DRE-1632852; Macroautophagy.
DR Reactome; R-DRE-165159; MTOR signalling.
DR Reactome; R-DRE-166208; mTORC1-mediated signalling.
DR Reactome; R-DRE-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DRE-5674135; MAP2K and MAPK activation.
DR Reactome; R-DRE-6798695; Neutrophil degranulation.
DR Reactome; R-DRE-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-DRE-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q503S6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR InterPro; IPR015019; LAMTOR3.
DR PANTHER; PTHR13378; PTHR13378; 1.
DR Pfam; PF08923; MAPKK1_Int; 1.
DR SMART; SM01278; MAPKK1_Int; 1.
PE 2: Evidence at transcript level;
KW Endosome; Membrane; Reference proteome.
FT CHAIN 1..124
FT /note="Ragulator complex protein LAMTOR3"
FT /id="PRO_0000356162"
SQ SEQUENCE 124 AA; 13677 MW; 1C279F409594D781 CRC64;
MADNLRSYLY KQLPSVEGLH AIVVTDRDGA PVIKVANDNA PEYALRPAFL STFALATDQG
SKLGLSKNKS IICYYSTYQI VQFNRLPLVI SFIASSNANT GLIFSLEKEL VPLIEELRQV
VEVA
