ID   LTOR3_DICDI             Reviewed;         132 AA.
AC   Q86J23; Q555R5;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Ragulator complex protein LAMTOR3 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
GN   ORFNames=DDB_G0274833;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. May activate the TOR signaling cascade in response to
CC       amino acids (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000012; EAL70309.1; -; Genomic_DNA.
DR   RefSeq; XP_643998.1; XM_638906.1.
DR   AlphaFoldDB; Q86J23; -.
DR   SMR; Q86J23; -.
DR   STRING; 44689.DDB0217502; -.
DR   PaxDb; Q86J23; -.
DR   EnsemblProtists; EAL70309; EAL70309; DDB_G0274833.
DR   GeneID; 8619424; -.
DR   KEGG; ddi:DDB_G0274833; -.
DR   dictyBase; DDB_G0274833; mapksp1.
DR   eggNOG; ENOG502SE9A; Eukaryota.
DR   HOGENOM; CLU_1921023_0_0_1; -.
DR   InParanoid; Q86J23; -.
DR   OMA; GAEDCNT; -.
DR   PhylomeDB; Q86J23; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-165159; MTOR signalling.
DR   Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR   Reactome; R-DDI-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DDI-5674135; MAP2K and MAPK activation.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q86J23; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0071986; C:Ragulator complex; IBA:GO_Central.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IBA:GO_Central.
DR   InterPro; IPR015019; LAMTOR3.
DR   PANTHER; PTHR13378; PTHR13378; 1.
DR   Pfam; PF08923; MAPKK1_Int; 1.
DR   SMART; SM01278; MAPKK1_Int; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..132
FT                   /note="Ragulator complex protein LAMTOR3 homolog"
FT                   /id="PRO_0000356168"
SQ   SEQUENCE   132 AA;  14408 MW;  9AD15CE58D7666F8 CRC64;
     MEKVDEFLEY IKVSILDKSI VDTSLILSDR DGFVLGKIID KSSSADNVID NSLISTFSSA
     TDQASKLHAG NNKSIVSFFE DRIIVHINVS NVILSIITDT ESNVGLILGS QDDLIRSLTS
     LSNSIQSDIQ DM