LTOR3_DROME
ID LTOR3_DROME Reviewed; 124 AA.
AC Q9VJD2;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ragulator complex protein LAMTOR3 homolog;
DE AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
GN ORFNames=CG5110;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION.
RX PubMed=20381137; DOI=10.1016/j.cell.2010.02.024;
RA Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M.;
RT "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is
RT necessary for its activation by amino acids.";
RL Cell 141:290-303(2010).
CC -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC promotes cell growth in response to growth factors, energy levels, and
CC amino acids. As part of the Ragulator complex, may activate the TOR
CC signaling cascade in response to amino acids.
CC {ECO:0000269|PubMed:20381137}.
CC -!- SUBUNIT: Part of the Ragulator complex composed of CG5110, CG5189,
CC CG14184, CG14812, and CG14977. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9VJD2; Q9V8I2: CG5189; NbExp=6; IntAct=EBI-111967, EBI-98229;
CC -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR EMBL; AE014134; AAF53620.1; -; Genomic_DNA.
DR EMBL; AY071010; AAL48632.1; -; mRNA.
DR RefSeq; NP_001246062.1; NM_001259133.2.
DR RefSeq; NP_609843.1; NM_135999.4.
DR AlphaFoldDB; Q9VJD2; -.
DR SMR; Q9VJD2; -.
DR BioGRID; 61051; 5.
DR DIP; DIP-17874N; -.
DR IntAct; Q9VJD2; 3.
DR STRING; 7227.FBpp0297292; -.
DR PaxDb; Q9VJD2; -.
DR PRIDE; Q9VJD2; -.
DR DNASU; 35055; -.
DR EnsemblMetazoa; FBtr0080983; FBpp0080536; FBgn0032642.
DR EnsemblMetazoa; FBtr0306162; FBpp0297292; FBgn0032642.
DR GeneID; 35055; -.
DR KEGG; dme:Dmel_CG5110; -.
DR UCSC; CG5110-RA; d. melanogaster.
DR FlyBase; FBgn0032642; CG5110.
DR VEuPathDB; VectorBase:FBgn0032642; -.
DR eggNOG; ENOG502RYGZ; Eukaryota.
DR GeneTree; ENSGT00390000013159; -.
DR HOGENOM; CLU_134641_0_0_1; -.
DR InParanoid; Q9VJD2; -.
DR OMA; GAEDCNT; -.
DR OrthoDB; 1525606at2759; -.
DR PhylomeDB; Q9VJD2; -.
DR Reactome; R-DME-1632852; Macroautophagy.
DR Reactome; R-DME-165159; MTOR signalling.
DR Reactome; R-DME-166208; mTORC1-mediated signalling.
DR Reactome; R-DME-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR Reactome; R-DME-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-DME-5674135; MAP2K and MAPK activation.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-DME-9639288; Amino acids regulate mTORC1.
DR BioGRID-ORCS; 35055; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35055; -.
DR PRO; PR:Q9VJD2; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032642; Expressed in mouthpart and 31 other tissues.
DR ExpressionAtlas; Q9VJD2; baseline and differential.
DR Genevisible; Q9VJD2; DM.
DR GO; GO:0071986; C:Ragulator complex; IMP:FlyBase.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IMP:FlyBase.
DR GO; GO:0032008; P:positive regulation of TOR signaling; IMP:UniProtKB.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IMP:FlyBase.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR InterPro; IPR015019; LAMTOR3.
DR PANTHER; PTHR13378; PTHR13378; 1.
DR Pfam; PF08923; MAPKK1_Int; 1.
DR SMART; SM01278; MAPKK1_Int; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..124
FT /note="Ragulator complex protein LAMTOR3 homolog"
FT /id="PRO_0000221007"
SQ SEQUENCE 124 AA; 13781 MW; 0F5E043D9D9C93E9 CRC64;
MSDDIKKYLD GLLQKVSGLY VIQITDRDGV PLLRVSQEKN VDFALMPSFI PTFTTACDQA
SKLGLGRNKT IISMYSNYQV VQMNKLPLIL TFVGAENCNT GHILALEHQV DGYLEDIKQA
VTEA
