ID   LTOR3_PAGMA             Reviewed;         124 AA.
AC   Q6Y228;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Ragulator complex protein LAMTOR3;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
GN   Name=lamtor3;
OS   Pagrus major (Red sea bream) (Chrysophrys major).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Pagrus.
OX   NCBI_TaxID=143350;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   AGRICOLA=IND43674139; DOI=10.1016/j.aquaculture.2004.07.008;
RA   Chen S.-L., Xu M.-Y., Hu S.-L., Li L.;
RT   "Analysis of immune-relevant genes expressed in red sea bream spleen.";
RL   Aquaculture 240:115-130(2004).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. {ECO:0000250|UniProtKB:O88653,
CC       ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR   EMBL; AY190710; AAP20185.1; -; mRNA.
DR   AlphaFoldDB; Q6Y228; -.
DR   SMR; Q6Y228; -.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   InterPro; IPR015019; LAMTOR3.
DR   PANTHER; PTHR13378; PTHR13378; 1.
DR   Pfam; PF08923; MAPKK1_Int; 1.
DR   SMART; SM01278; MAPKK1_Int; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane.
FT   CHAIN           1..124
FT                   /note="Ragulator complex protein LAMTOR3"
FT                   /id="PRO_0000356163"
SQ   SEQUENCE   124 AA;  13721 MW;  D6803482D85AAB18 CRC64;
     MADDLKRYLY KQLQSVEGLH AIVVTDRDGV PVIKVANDNA PVHALRPGFL STFALATDQG
     SKLGLSKNKS IICYYNTYQI VQFNRLPLVI SFIASSNANT GLIMSLEKEL APLIEELRQV
     VEVT