LTOR3_RAT
ID LTOR3_RAT Reviewed; 124 AA.
AC Q5U204;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Ragulator complex protein LAMTOR3;
DE AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
DE AltName: Full=Mitogen-activated protein kinase kinase 1-interacting protein 1;
GN Name=Lamtor3; Synonyms=Map2k1ip1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: As part of the Ragulator complex it is involved in amino acid
CC sensing and activation of mTORC1, a signaling complex promoting cell
CC growth in response to growth factors, energy levels, and amino acids.
CC Activated by amino acids through a mechanism involving the lysosomal V-
CC ATPase, the Ragulator functions as a guanine nucleotide exchange factor
CC activating the small GTPases Rag. Activated Ragulator and Rag GTPases
CC function as a scaffold recruiting mTORC1 to lysosomes where it is in
CC turn activated. Adapter protein that enhances the efficiency of the MAP
CC kinase cascade facilitating the activation of MAPK2 (By similarity).
CC {ECO:0000250|UniProtKB:Q9UHA4}.
CC -!- SUBUNIT: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2,
CC LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer
CC that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer.
CC Interacts with LAMTOR1 and LAMTOR2; the interaction is direct. The
CC Ragulator complex interacts with both the mTORC1 complex and
CC heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and
CC RRAGD; regulated by amino acid availability. The Ragulator complex
CC interacts with SLC38A9; the probable amino acid sensor. Component of
CC the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or
CC FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD
CC GTP-bound, and Ragulator (By similarity). Interacts with MAP2K1/MEK1
CC and MAPK2 (By similarity). Interacts with MORG1 (By similarity).
CC {ECO:0000250|UniProtKB:O88653, ECO:0000250|UniProtKB:Q9UHA4}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR EMBL; BC086353; AAH86353.1; -; mRNA.
DR RefSeq; NP_001008376.1; NM_001008375.1.
DR RefSeq; XP_006233445.1; XM_006233383.3.
DR RefSeq; XP_006233447.1; XM_006233385.3.
DR AlphaFoldDB; Q5U204; -.
DR SMR; Q5U204; -.
DR IntAct; Q5U204; 1.
DR STRING; 10116.ENSRNOP00000014027; -.
DR iPTMnet; Q5U204; -.
DR PhosphoSitePlus; Q5U204; -.
DR jPOST; Q5U204; -.
DR PaxDb; Q5U204; -.
DR PRIDE; Q5U204; -.
DR GeneID; 362045; -.
DR KEGG; rno:362045; -.
DR CTD; 8649; -.
DR RGD; 1307133; Lamtor3.
DR VEuPathDB; HostDB:ENSRNOG00000010552; -.
DR eggNOG; ENOG502RYGZ; Eukaryota.
DR HOGENOM; CLU_134641_0_0_1; -.
DR InParanoid; Q5U204; -.
DR OMA; FLYKQMQ; -.
DR OrthoDB; 1525606at2759; -.
DR PhylomeDB; Q5U204; -.
DR TreeFam; TF324889; -.
DR Reactome; R-RNO-1632852; Macroautophagy.
DR Reactome; R-RNO-165159; MTOR signalling.
DR Reactome; R-RNO-166208; mTORC1-mediated signalling.
DR Reactome; R-RNO-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR Reactome; R-RNO-5628897; TP53 Regulates Metabolic Genes.
DR Reactome; R-RNO-5674135; MAP2K and MAPK activation.
DR Reactome; R-RNO-6798695; Neutrophil degranulation.
DR Reactome; R-RNO-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-RNO-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q5U204; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000010552; Expressed in heart and 20 other tissues.
DR Genevisible; Q5U204; RN.
DR GO; GO:0005770; C:late endosome; ISO:RGD.
DR GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0019209; F:kinase activator activity; ISO:RGD.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:1902414; P:protein localization to cell junction; ISO:RGD.
DR InterPro; IPR015019; LAMTOR3.
DR PANTHER; PTHR13378; PTHR13378; 1.
DR Pfam; PF08923; MAPKK1_Int; 1.
DR SMART; SM01278; MAPKK1_Int; 1.
PE 2: Evidence at transcript level;
KW Endosome; Membrane; Reference proteome.
FT CHAIN 1..124
FT /note="Ragulator complex protein LAMTOR3"
FT /id="PRO_0000240658"
FT REGION 57..70
FT /note="Required for interaction with LAMTOR2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 124 AA; 13580 MW; 3B9C8A1E901506A9 CRC64;
MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL STFALATDQG
SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSNANT GLIVSLEKEL APLFEELIKV
VEVS
