LTOR3_TETNG
ID LTOR3_TETNG Reviewed; 124 AA.
AC Q4SSF5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Ragulator complex protein LAMTOR3;
DE AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
GN Name=lamtor3; ORFNames=GSTENG00013453001;
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
CC -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC promotes cell growth in response to growth factors, energy levels, and
CC amino acids. As part of the Ragulator complex, may activate the TOR
CC signaling cascade in response to amino acids. Adapter protein that may
CC regulate the MAP kinase cascade. {ECO:0000250|UniProtKB:Q9UHA4}.
CC -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC slc38a9; the probable amino acid sensor. Component of the lysosomal
CC folliculin complex (LFC). {ECO:0000250|UniProtKB:O88653,
CC ECO:0000250|UniProtKB:Q9UHA4}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR EMBL; CAAE01014454; CAF96427.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4SSF5; -.
DR SMR; Q4SSF5; -.
DR STRING; 99883.ENSTNIP00000009796; -.
DR Ensembl; ENSTNIT00000009974; ENSTNIP00000009796; ENSTNIG00000006997.
DR KEGG; tng:GSTEN00013453G001; -.
DR GeneTree; ENSGT00390000013159; -.
DR HOGENOM; CLU_134641_0_0_1; -.
DR InParanoid; Q4SSF5; -.
DR OMA; FLYKQMQ; -.
DR TreeFam; TF324889; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR InterPro; IPR015019; LAMTOR3.
DR PANTHER; PTHR13378; PTHR13378; 1.
DR Pfam; PF08923; MAPKK1_Int; 1.
DR SMART; SM01278; MAPKK1_Int; 1.
PE 3: Inferred from homology;
KW Endosome; Membrane; Reference proteome.
FT CHAIN 1..124
FT /note="Ragulator complex protein LAMTOR3"
FT /id="PRO_0000356164"
SQ SEQUENCE 124 AA; 13681 MW; DE38AC6C75F7B143 CRC64;
MADDLKRYLY KQLQSVEGLH AIVVTDRDGV PVVKVANDNA PVPALRPGFL STFALATDQG
SKLGLSKNKS IICYYNDYQI VQFNRLPLVI SFIARSSANT GLIMSLENEL APLIEELKQV
VEVT