ID   LTOR3_XENTR             Reviewed;         124 AA.
AC   B4F6Y3;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Ragulator complex protein LAMTOR3;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3;
DE   AltName: Full=Mitogen-activated protein kinase scaffold protein 1;
GN   Name=lamtor3; Synonyms=mapksp1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=PopA;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade. {ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:O88653,
CC       ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR   EMBL; BC168057; AAI68057.1; -; mRNA.
DR   RefSeq; NP_001135566.1; NM_001142094.1.
DR   AlphaFoldDB; B4F6Y3; -.
DR   SMR; B4F6Y3; -.
DR   STRING; 8364.ENSXETP00000056222; -.
DR   PaxDb; B4F6Y3; -.
DR   GeneID; 100216113; -.
DR   KEGG; xtr:100216113; -.
DR   CTD; 100216113; -.
DR   Xenbase; XB-GENE-942321; lamtor3-like.
DR   eggNOG; ENOG502RYGZ; Eukaryota.
DR   InParanoid; B4F6Y3; -.
DR   OrthoDB; 1525606at2759; -.
DR   Reactome; R-XTR-1632852; Macroautophagy.
DR   Reactome; R-XTR-165159; MTOR signalling.
DR   Reactome; R-XTR-166208; mTORC1-mediated signalling.
DR   Reactome; R-XTR-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-XTR-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-XTR-5674135; MAP2K and MAPK activation.
DR   Reactome; R-XTR-6798695; Neutrophil degranulation.
DR   Reactome; R-XTR-9639288; Amino acids regulate mTORC1.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   InterPro; IPR015019; LAMTOR3.
DR   PANTHER; PTHR13378; PTHR13378; 1.
DR   Pfam; PF08923; MAPKK1_Int; 1.
DR   SMART; SM01278; MAPKK1_Int; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Reference proteome.
FT   CHAIN           1..124
FT                   /note="Ragulator complex protein LAMTOR3"
FT                   /id="PRO_0000356167"
SQ   SEQUENCE   124 AA;  13761 MW;  1508E7CD0958596E CRC64;
     MAEELRRFLY KKLTSVDELH AIVVSDRDGV PVIKVANENA PEHALRPAFL STFALATDQG
     SKLGLSKNKS IICYYSTYQV VQFNQLPLVV SFIASCNANT GLILSLEEEL GSLFKELRQV
     VEIS