ID   LTOR4_BOVIN             Reviewed;          99 AA.
AC   Q2M2U3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Ragulator complex protein LAMTOR4;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
DE   Contains:
DE     RecName: Full=Ragulator complex protein LAMTOR4, N-terminally processed;
GN   Name=LAMTOR4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As part of the Ragulator complex it is involved in amino acid
CC       sensing and activation of mTORC1, a signaling complex promoting cell
CC       growth in response to growth factors, energy levels, and amino acids.
CC       Activated by amino acids through a mechanism involving the lysosomal V-
CC       ATPase, the Ragulator functions as a guanine nucleotide exchange factor
CC       activating the small GTPases Rag. Activated Ragulator and Rag GTPases
CC       function as a scaffold recruiting mTORC1 to lysosomes where it is in
CC       turn activated (By similarity). {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of LAMTOR1, LAMTOR2,
CC       LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer
CC       that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer.
CC       The Ragulator complex interacts with both the mTORC1 complex and
CC       heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and
CC       RRAGD; regulated by amino acid availability. The Ragulator complex
CC       interacts with SLC38A9; the probable amino acid sensor. Component of
CC       the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or
CC       FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD
CC       GTP-bound, and Ragulator. {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SIMILARITY: Belongs to the LAMTOR4 family. {ECO:0000305}.
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DR   EMBL; BC111612; AAI11613.2; -; mRNA.
DR   RefSeq; NP_001160079.1; NM_001166607.1.
DR   AlphaFoldDB; Q2M2U3; -.
DR   SMR; Q2M2U3; -.
DR   STRING; 9913.ENSBTAP00000019980; -.
DR   PaxDb; Q2M2U3; -.
DR   PRIDE; Q2M2U3; -.
DR   Ensembl; ENSBTAT00000019980; ENSBTAP00000019980; ENSBTAG00000015009.
DR   GeneID; 511903; -.
DR   KEGG; bta:511903; -.
DR   CTD; 389541; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015009; -.
DR   VGNC; VGNC:30782; LAMTOR4.
DR   eggNOG; ENOG502S3B2; Eukaryota.
DR   GeneTree; ENSGT00390000016053; -.
DR   HOGENOM; CLU_137556_1_0_1; -.
DR   InParanoid; Q2M2U3; -.
DR   OMA; CRFRLHG; -.
DR   OrthoDB; 1589714at2759; -.
DR   TreeFam; TF324352; -.
DR   Reactome; R-BTA-1632852; Macroautophagy.
DR   Reactome; R-BTA-165159; MTOR signalling.
DR   Reactome; R-BTA-166208; mTORC1-mediated signalling.
DR   Reactome; R-BTA-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-BTA-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-BTA-9639288; Amino acids regulate mTORC1.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000015009; Expressed in anterior segment of eyeball and 106 other tissues.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR034601; LAMTOR4.
DR   PANTHER; PTHR33967; PTHR33967; 1.
PE   3: Inferred from homology;
KW   Acetylation; Lysosome; Reference proteome.
FT   CHAIN           1..99
FT                   /note="Ragulator complex protein LAMTOR4"
FT                   /id="PRO_0000424497"
FT   INIT_MET        1
FT                   /note="Removed; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q0VGL1"
FT   CHAIN           2..99
FT                   /note="Ragulator complex protein LAMTOR4, N-terminally
FT                   processed"
FT                   /id="PRO_0000325840"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q0VGL1"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine; in Ragulator complex protein
FT                   LAMTOR4, N-terminally processed"
FT                   /evidence="ECO:0000250|UniProtKB:Q0VGL1"
SQ   SEQUENCE   99 AA;  10686 MW;  859B6C92F0165DFB CRC64;
     MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA CGFRLHQGMS
     VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV