ID   LTOR4_DANRE             Reviewed;          99 AA.
AC   Q0P3X8; Q5RGI9;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Ragulator complex protein LAMTOR4;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
GN   Name=lamtor4; ORFNames=si:dkey-159a18.7;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SIMILARITY: Belongs to the LAMTOR4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI20698.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BX890616; CAI20698.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BC122392; AAI22393.1; -; mRNA.
DR   RefSeq; NP_001038415.1; NM_001044950.1.
DR   AlphaFoldDB; Q0P3X8; -.
DR   SMR; Q0P3X8; -.
DR   STRING; 7955.ENSDARP00000115287; -.
DR   PaxDb; Q0P3X8; -.
DR   Ensembl; ENSDART00000143642; ENSDARP00000115287; ENSDARG00000045542.
DR   GeneID; 561019; -.
DR   KEGG; dre:561019; -.
DR   CTD; 389541; -.
DR   ZFIN; ZDB-GENE-030131-7438; lamtor4.
DR   eggNOG; ENOG502S3B2; Eukaryota.
DR   GeneTree; ENSGT00390000016053; -.
DR   HOGENOM; CLU_137556_1_0_1; -.
DR   InParanoid; Q0P3X8; -.
DR   OMA; CRFRLHG; -.
DR   OrthoDB; 1589714at2759; -.
DR   PhylomeDB; Q0P3X8; -.
DR   TreeFam; TF324352; -.
DR   Reactome; R-DRE-1632852; Macroautophagy.
DR   Reactome; R-DRE-165159; MTOR signalling.
DR   Reactome; R-DRE-166208; mTORC1-mediated signalling.
DR   Reactome; R-DRE-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-DRE-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DRE-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DRE-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q0P3X8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000045542; Expressed in mature ovarian follicle and 27 other tissues.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR034601; LAMTOR4.
DR   PANTHER; PTHR33967; PTHR33967; 1.
PE   3: Inferred from homology;
KW   Lysosome; Reference proteome.
FT   CHAIN           1..99
FT                   /note="Ragulator complex protein LAMTOR4"
FT                   /id="PRO_0000325844"
SQ   SEQUENCE   99 AA;  11101 MW;  247B1DCC37C4A01E CRC64;
     MTTALTQGLE RIPDQLGYLV ISEDGVLASA GELENDEHTA GVIMQMVRTA CRFRLHGTAE
     PPFKRMSVMF EDYVYAVTIS GQKVFVVKRQ NNQREPVIV