ID   LTOR4_DICDI             Reviewed;          87 AA.
AC   Q54DY3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Ragulator complex protein LAMTOR4 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
GN   ORFNames=DDB_G0291948;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AX4;
RX   PubMed=15010511; DOI=10.1093/nar/gkh262;
RA   Urushihara H., Morio T., Saito T., Kohara Y., Koriki E., Ochiai H.,
RA   Maeda M., Williams J.G., Takeuchi I., Tanaka Y.;
RT   "Analyses of cDNAs from growth and slug stages of Dictyostelium
RT   discoideum.";
RL   Nucleic Acids Res. 32:1647-1653(2004).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR4 family. {ECO:0000305}.
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DR   EMBL; AAFI02000186; EAL61504.1; -; Genomic_DNA.
DR   EMBL; AU266846; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_629913.1; XM_629911.1.
DR   AlphaFoldDB; Q54DY3; -.
DR   SMR; Q54DY3; -.
DR   STRING; 44689.DDB0215476; -.
DR   PaxDb; Q54DY3; -.
DR   EnsemblProtists; EAL61504; EAL61504; DDB_G0291948.
DR   GeneID; 8628414; -.
DR   KEGG; ddi:DDB_G0291948; -.
DR   dictyBase; DDB_G0291948; -.
DR   eggNOG; ENOG502RIB0; Eukaryota.
DR   HOGENOM; CLU_2488105_0_0_1; -.
DR   InParanoid; Q54DY3; -.
DR   OMA; KRMTITF; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-165159; MTOR signalling.
DR   Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR   Reactome; R-DDI-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DDI-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q54DY3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR034601; LAMTOR4.
DR   PANTHER; PTHR33967; PTHR33967; 1.
PE   3: Inferred from homology;
KW   Lysosome; Reference proteome.
FT   CHAIN           1..87
FT                   /note="Ragulator complex protein LAMTOR4 homolog"
FT                   /id="PRO_0000325848"
SQ   SEQUENCE   87 AA;  9629 MW;  69FEA018ADD3E703 CRC64;
     MSAPDILKDF KGSLTIEQDG SISSASGILQ ESFYNNKEFA STIISMLHDV NKITSSNNQE
     FKRMTVSFSE QTFIVTAIGT KIYVVVQ