ID   LTOR4_DROPS             Reviewed;         121 AA.
AC   Q29EZ6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Ragulator complex protein LAMTOR4 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
GN   ORFNames=GA13399;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR4 family. {ECO:0000305}.
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DR   EMBL; CH379070; EAL29913.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q29EZ6; -.
DR   SMR; Q29EZ6; -.
DR   STRING; 7237.FBpp0286641; -.
DR   eggNOG; ENOG502S3B2; Eukaryota.
DR   HOGENOM; CLU_137556_0_0_1; -.
DR   InParanoid; Q29EZ6; -.
DR   OMA; DESFMPN; -.
DR   PhylomeDB; Q29EZ6; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR034601; LAMTOR4.
DR   PANTHER; PTHR33967; PTHR33967; 1.
PE   3: Inferred from homology;
KW   Lysosome; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Ragulator complex protein LAMTOR4 homolog"
FT                   /id="PRO_0000325847"
FT   REGION          91..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   121 AA;  13296 MW;  4091C19FC7E259A7 CRC64;
     MDKEKLIAPN QMGYLILKDD GNLLDSGGDL KNDDRSANVI MGLLNLTDSI DEDFMPNSSC
     ERITIDYDQH YYSICMSNRR IYVVKLSKTH TQNGATTSSS SSTSYNDAAE GNNISSSTVL
     A