ID   LTOR4_NEMVE             Reviewed;          95 AA.
AC   A7S6M8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Ragulator complex protein LAMTOR4 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
GN   ORFNames=v1g232793;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS469588; EDO40683.1; -; Genomic_DNA.
DR   RefSeq; XP_001632746.1; XM_001632696.1.
DR   AlphaFoldDB; A7S6M8; -.
DR   SMR; A7S6M8; -.
DR   STRING; 45351.EDO40683; -.
DR   EnsemblMetazoa; EDO40683; EDO40683; NEMVEDRAFT_v1g232793.
DR   GeneID; 5512379; -.
DR   KEGG; nve:5512379; -.
DR   eggNOG; ENOG502S3B2; Eukaryota.
DR   HOGENOM; CLU_137556_1_0_1; -.
DR   InParanoid; A7S6M8; -.
DR   OMA; CRFRLHG; -.
DR   OrthoDB; 1589714at2759; -.
DR   PhylomeDB; A7S6M8; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR034601; LAMTOR4.
DR   PANTHER; PTHR33967; PTHR33967; 1.
PE   3: Inferred from homology;
KW   Lysosome; Reference proteome.
FT   CHAIN           1..95
FT                   /note="Ragulator complex protein LAMTOR4 homolog"
FT                   /id="PRO_0000366120"
SQ   SEQUENCE   95 AA;  10084 MW;  0E0655EBB34DB45D CRC64;
     MAGSTYGLDK IAGVQGYLVV NPDGAVLASS GDLENDEKTA GVIVDMLQTA SMIPLSGDSS
     HSLKRLSVHF GNFVLMATVT NQRIFIVKRP TTETE