ID   LTOR4_XENTR             Reviewed;          99 AA.
AC   A9UMU8; B7ZUJ2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Ragulator complex protein LAMTOR4;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
GN   Name=lamtor4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula, and Small intestine;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q0VGL1}.
CC   -!- SIMILARITY: Belongs to the LAMTOR4 family. {ECO:0000305}.
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DR   EMBL; BC157803; AAI57804.1; -; mRNA.
DR   EMBL; BC171250; AAI71250.1; -; mRNA.
DR   EMBL; BC171276; AAI71276.1; -; mRNA.
DR   RefSeq; NP_001107543.1; NM_001114071.1.
DR   AlphaFoldDB; A9UMU8; -.
DR   SMR; A9UMU8; -.
DR   GeneID; 100135410; -.
DR   KEGG; xtr:100135410; -.
DR   CTD; 389541; -.
DR   Xenbase; XB-GENE-6454976; lamtor4.
DR   InParanoid; A9UMU8; -.
DR   Reactome; R-XTR-1632852; Macroautophagy.
DR   Reactome; R-XTR-165159; MTOR signalling.
DR   Reactome; R-XTR-166208; mTORC1-mediated signalling.
DR   Reactome; R-XTR-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-XTR-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-XTR-9639288; Amino acids regulate mTORC1.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR034601; LAMTOR4.
DR   PANTHER; PTHR33967; PTHR33967; 1.
PE   3: Inferred from homology;
KW   Lysosome; Reference proteome.
FT   CHAIN           1..99
FT                   /note="Ragulator complex protein LAMTOR4"
FT                   /id="PRO_0000325845"
SQ   SEQUENCE   99 AA;  10966 MW;  B9E497A218F8D709 CRC64;
     MTSTMTQGLE RIPDQMGYLV MSEDGGVLAS AGDLENDERL AGVIREMVAV ACSFRDLGDQ
     QPFKRMSIVF GEHTFLVTIS GQKIYVVKRQ NVVREPISV