ID   LTOR5_DICDI             Reviewed;          89 AA.
AC   Q54QW5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Ragulator complex protein LAMTOR5 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5;
GN   ORFNames=DDB_G0283567;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR5 family. {ECO:0000305}.
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DR   EMBL; AAFI02000055; EAL65661.1; -; Genomic_DNA.
DR   RefSeq; XP_639019.1; XM_633927.1.
DR   AlphaFoldDB; Q54QW5; -.
DR   SMR; Q54QW5; -.
DR   STRING; 44689.DDB0238095; -.
DR   PaxDb; Q54QW5; -.
DR   EnsemblProtists; EAL65661; EAL65661; DDB_G0283567.
DR   GeneID; 8624149; -.
DR   KEGG; ddi:DDB_G0283567; -.
DR   dictyBase; DDB_G0283567; -.
DR   eggNOG; ENOG502RIFA; Eukaryota.
DR   HOGENOM; CLU_164970_0_0_1; -.
DR   InParanoid; Q54QW5; -.
DR   OMA; VDQISHI; -.
DR   PhylomeDB; Q54QW5; -.
DR   Reactome; R-DDI-1632852; Macroautophagy.
DR   Reactome; R-DDI-165159; MTOR signalling.
DR   Reactome; R-DDI-166208; mTORC1-mediated signalling.
DR   Reactome; R-DDI-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-DDI-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-DDI-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q54QW5; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR024135; LAMTOR5.
DR   PANTHER; PTHR13342; PTHR13342; 1.
DR   Pfam; PF16672; LAMTOR5; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lysosome; Reference proteome.
FT   CHAIN           1..89
FT                   /note="Ragulator complex protein LAMTOR5 homolog"
FT                   /id="PRO_0000331600"
SQ   SEQUENCE   89 AA;  9686 MW;  2EFEB5DC4BCA4F28 CRC64;
     MDKQLADTFT QLSQQNGVVG YCCVDESGLC LKAHGNKQSS NAGFYKSLLD KSKFLTQSGE
     PANIVIETDT ANIFIQQNDK ITLSVSKLP