ID   LTOR5_IXOSC             Reviewed;          91 AA.
AC   Q4PM15;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Ragulator complex protein LAMTOR5 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5;
OS   Ixodes scapularis (Black-legged tick) (Deer tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX   NCBI_TaxID=6945;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=IS-6-12L-315; TISSUE=Salivary gland;
RX   PubMed=16431279; DOI=10.1016/j.ibmb.2005.11.005;
RA   Ribeiro J.M.C., Alarcon-Chaidez F., Francischetti I.M.B., Mans B.J.,
RA   Mather T.N., Valenzuela J.G., Wikel S.K.;
RT   "An annotated catalog of salivary gland transcripts from Ixodes scapularis
RT   ticks.";
RL   Insect Biochem. Mol. Biol. 36:111-129(2006).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR5 family. {ECO:0000305}.
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DR   EMBL; DQ066313; AAY66950.1; -; mRNA.
DR   AlphaFoldDB; Q4PM15; -.
DR   SMR; Q4PM15; -.
DR   VEuPathDB; VectorBase:ISCI006790; -.
DR   VEuPathDB; VectorBase:ISCW006790; -.
DR   Proteomes; UP000001555; Unplaced.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR024135; LAMTOR5.
DR   PANTHER; PTHR13342; PTHR13342; 1.
DR   Pfam; PF16672; LAMTOR5; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lysosome; Reference proteome.
FT   CHAIN           1..91
FT                   /note="Ragulator complex protein LAMTOR5 homolog"
FT                   /id="PRO_0000331598"
SQ   SEQUENCE   91 AA;  9565 MW;  2C01DB102E7F9264 CRC64;
     MEAPLVKCLD EILDSGAVGV ICADKDGLAL HSAGQVQLRA AGVITALASL AKQIDPSCDT
     TPTIHLESDS LDVYIQQKEQ VSLAVYSTPK K