ID   LTOR5_NEMVE             Reviewed;          91 AA.
AC   A7RT29;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Ragulator complex protein LAMTOR5 homolog;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5;
GN   ORFNames=v1g226489;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the Ragulator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR5 family. {ECO:0000305}.
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DR   EMBL; DS469536; EDO45318.1; -; Genomic_DNA.
DR   RefSeq; XP_001637381.1; XM_001637331.1.
DR   AlphaFoldDB; A7RT29; -.
DR   SMR; A7RT29; -.
DR   STRING; 45351.EDO45318; -.
DR   EnsemblMetazoa; EDO45318; EDO45318; NEMVEDRAFT_v1g226489.
DR   GeneID; 5517381; -.
DR   KEGG; nve:5517381; -.
DR   eggNOG; ENOG502S5TK; Eukaryota.
DR   HOGENOM; CLU_164970_0_0_1; -.
DR   InParanoid; A7RT29; -.
DR   OMA; AKGNINP; -.
DR   OrthoDB; 1582960at2759; -.
DR   PhylomeDB; A7RT29; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR024135; LAMTOR5.
DR   PANTHER; PTHR13342; PTHR13342; 1.
DR   Pfam; PF16672; LAMTOR5; 1.
DR   PRINTS; PR02092; HEPBVIRUSXIP.
PE   3: Inferred from homology;
KW   Cytoplasm; Lysosome; Reference proteome.
FT   CHAIN           1..91
FT                   /note="Ragulator complex protein LAMTOR5 homolog"
FT                   /id="PRO_0000331599"
SQ   SEQUENCE   91 AA;  9738 MW;  5F0C895FEADBD2E7 CRC64;
     MEKDLESHVD DVMSEHGVVG VMCTDDQGLS LIAKGTANPA TAGFVQNLAE SARKLYPDSE
     QQPVICLESD ACNLLIKSQN KVTIAVHKVP S