ID   LTOR5_XENLA             Reviewed;          91 AA.
AC   Q6IRS2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Ragulator complex protein LAMTOR5;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5;
GN   Name=lamtor5; Synonyms=hbxip;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250|UniProtKB:O43504}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:O43504}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43504}.
CC       Lysosome {ECO:0000250|UniProtKB:O43504}.
CC   -!- SIMILARITY: Belongs to the LAMTOR5 family. {ECO:0000305}.
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DR   EMBL; BC070520; AAH70520.1; -; mRNA.
DR   RefSeq; NP_001084999.1; NM_001091530.1.
DR   RefSeq; XP_018103694.1; XM_018248205.1.
DR   AlphaFoldDB; Q6IRS2; -.
DR   SMR; Q6IRS2; -.
DR   DNASU; 432061; -.
DR   GeneID; 432061; -.
DR   KEGG; xla:432061; -.
DR   CTD; 432061; -.
DR   Xenbase; XB-GENE-6256281; lamtor5.S.
DR   OMA; AKGNINP; -.
DR   OrthoDB; 1582960at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 432061; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR024135; LAMTOR5.
DR   PANTHER; PTHR13342; PTHR13342; 1.
DR   Pfam; PF16672; LAMTOR5; 1.
DR   PRINTS; PR02092; HEPBVIRUSXIP.
PE   3: Inferred from homology;
KW   Cytoplasm; Lysosome; Reference proteome.
FT   CHAIN           1..91
FT                   /note="Ragulator complex protein LAMTOR5"
FT                   /id="PRO_0000331596"
SQ   SEQUENCE   91 AA;  9642 MW;  6958DD3F26F16042 CRC64;
     MEAALEQHLE DTMKNPSIVG VLCTDSQGLN LGCCGSLSDK HAGVISILPQ YAAKLTTDPT
     DVPVVCLESD NGTVMIQKHD HLTVAVHKVT S