ID   LTOR5_XENTR             Reviewed;          91 AA.
AC   A9UL91;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Ragulator complex protein LAMTOR5;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5;
GN   Name=lamtor5; Synonyms=hbxip;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids (By similarity).
CC       {ECO:0000250|UniProtKB:O43504}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:O43504}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43504}.
CC       Lysosome {ECO:0000250|UniProtKB:O43504}.
CC   -!- SIMILARITY: Belongs to the LAMTOR5 family. {ECO:0000305}.
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DR   EMBL; BC157166; AAI57167.1; -; mRNA.
DR   RefSeq; NP_001107345.1; NM_001113873.1.
DR   AlphaFoldDB; A9UL91; -.
DR   SMR; A9UL91; -.
DR   STRING; 8364.ENSXETP00000054622; -.
DR   PaxDb; A9UL91; -.
DR   Ensembl; ENSXETT00000103950; ENSXETP00000098714; ENSXETG00000040956.
DR   GeneID; 100135168; -.
DR   KEGG; xtr:100135168; -.
DR   CTD; 10542; -.
DR   Xenbase; XB-GENE-950195; lamtor5.
DR   eggNOG; ENOG502S5TK; Eukaryota.
DR   HOGENOM; CLU_164970_0_0_1; -.
DR   InParanoid; A9UL91; -.
DR   OMA; MCLESDN; -.
DR   OrthoDB; 1405682at2759; -.
DR   PhylomeDB; A9UL91; -.
DR   TreeFam; TF324433; -.
DR   Reactome; R-XTR-1632852; Macroautophagy.
DR   Reactome; R-XTR-165159; MTOR signalling.
DR   Reactome; R-XTR-166208; mTORC1-mediated signalling.
DR   Reactome; R-XTR-380972; Energy dependent regulation of mTOR by LKB1-AMPK.
DR   Reactome; R-XTR-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-XTR-9639288; Amino acids regulate mTORC1.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000040956; Expressed in testis and 13 other tissues.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0061462; P:protein localization to lysosome; ISS:UniProtKB.
DR   GO; GO:0008361; P:regulation of cell size; ISS:UniProtKB.
DR   InterPro; IPR024135; LAMTOR5.
DR   PANTHER; PTHR13342; PTHR13342; 1.
DR   Pfam; PF16672; LAMTOR5; 1.
DR   PRINTS; PR02092; HEPBVIRUSXIP.
PE   3: Inferred from homology;
KW   Cytoplasm; Lysosome; Reference proteome.
FT   CHAIN           1..91
FT                   /note="Ragulator complex protein LAMTOR5"
FT                   /id="PRO_0000331597"
SQ   SEQUENCE   91 AA;  9613 MW;  78B93CB453FC7D42 CRC64;
     MEAALEQHLE DTMKNPSIVG VLCTDSQGLS LGCCGSLSDK HAGVISILPQ YAAKLTSDPT
     DVPVVCLESD NGIVMIQKHD HLTVAVHKVT S