ID   LTR2A_XENLA             Reviewed;         125 AA.
AC   Q63ZJ2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Ragulator complex protein LAMTOR2-A;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2-A;
DE   AltName: Full=Roadblock domain-containing protein 3;
GN   Name=lamtor2-a; Synonyms=robld3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:Q9Y2Q5}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Lysosome membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GAMAD family. {ECO:0000305}.
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DR   EMBL; BC082921; AAH82921.1; -; mRNA.
DR   RefSeq; NP_001088121.1; NM_001094652.1.
DR   AlphaFoldDB; Q63ZJ2; -.
DR   SMR; Q63ZJ2; -.
DR   DNASU; 494825; -.
DR   GeneID; 494825; -.
DR   KEGG; xla:494825; -.
DR   CTD; 494825; -.
DR   Xenbase; XB-GENE-992367; lamtor2.L.
DR   OMA; WSAYERT; -.
DR   OrthoDB; 1515483at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 494825; Expressed in liver and 20 other tissues.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0001558; P:regulation of cell growth; ISS:UniProtKB.
DR   InterPro; IPR037587; LAMTOR2-like.
DR   InterPro; IPR004942; Roadblock/LAMTOR2_dom.
DR   PANTHER; PTHR13323; PTHR13323; 1.
DR   Pfam; PF03259; Robl_LC7; 1.
DR   SMART; SM00960; Robl_LC7; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Ragulator complex protein LAMTOR2-A"
FT                   /id="PRO_0000365942"
FT   REGION          57..70
FT                   /note="Required for location at endosomes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13549 MW;  C2F440634A662346 CRC64;
     MLRPKALTQV LSQANTGGVQ STLLLNNEGS LLAYSGYGDT DARVTAAIAS NIWAAYDKNG
     HQAFNEDNLK LILMDCMEGR VAITRVSNLL LCMYAKETVG FGMLKAKAQA LVYYLEEPLN
     QVSSA