ID   LTR3A_XENLA             Reviewed;         123 AA.
AC   Q7T0V2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Ragulator complex protein LAMTOR3-A;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-A;
DE   AltName: Full=Mitogen-activated protein kinase scaffold protein 1;
GN   Name=lamtor3-a; Synonyms=mapksp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade. {ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:O88653,
CC       ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
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DR   EMBL; BC056026; AAH56026.1; -; mRNA.
DR   RefSeq; NP_001080876.1; NM_001087407.1.
DR   RefSeq; XP_018117172.1; XM_018261683.1.
DR   AlphaFoldDB; Q7T0V2; -.
DR   SMR; Q7T0V2; -.
DR   DNASU; 380570; -.
DR   GeneID; 380570; -.
DR   KEGG; xla:380570; -.
DR   CTD; 380570; -.
DR   Xenbase; XB-GENE-6253417; lamtor3-like.L.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 380570; Expressed in brain and 19 other tissues.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   InterPro; IPR015019; LAMTOR3.
DR   PANTHER; PTHR13378; PTHR13378; 1.
DR   Pfam; PF08923; MAPKK1_Int; 1.
DR   SMART; SM01278; MAPKK1_Int; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Reference proteome.
FT   CHAIN           1..123
FT                   /note="Ragulator complex protein LAMTOR3-A"
FT                   /id="PRO_0000356165"
SQ   SEQUENCE   123 AA;  13520 MW;  50F71B9D5AD5F3F0 CRC64;
     MAEELRRFLY KKLTSVEGLH AIVVSDRDGV PVIKVANENA PEQALRPAFL STFALATDQG
     SKLGLSKNKS IICYYSTYQV VQFNQLPLVV SFIASSNANT GLILSLEKEL GSLFKELRQA
     VIS