ID   LTR3B_XENLA             Reviewed;         123 AA.
AC   Q7T0T2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Ragulator complex protein LAMTOR3-B;
DE   AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3-B;
DE   AltName: Full=Mitogen-activated protein kinase scaffold protein 1;
GN   Name=lamtor3-b; Synonyms=mapksp1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of the TOR pathway, a signaling cascade that
CC       promotes cell growth in response to growth factors, energy levels, and
CC       amino acids. As part of the Ragulator complex, may activate the TOR
CC       signaling cascade in response to amino acids. Adapter protein that may
CC       regulate the MAP kinase cascade. {ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBUNIT: Part of the Ragulator complex composed of lamtor1, lamtor2,
CC       lamtor3, lamtor4 and lamtor5. The Ragulator complex interacts with
CC       slc38a9; the probable amino acid sensor. Component of the lysosomal
CC       folliculin complex (LFC). {ECO:0000250|UniProtKB:O88653,
CC       ECO:0000250|UniProtKB:Q9UHA4}.
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LAMTOR3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC056049; AAH56049.1; -; mRNA.
DR   RefSeq; NP_001079867.1; NM_001086398.1.
DR   RefSeq; XP_018119371.1; XM_018263882.1.
DR   AlphaFoldDB; Q7T0T2; -.
DR   SMR; Q7T0T2; -.
DR   DNASU; 379557; -.
DR   GeneID; 379557; -.
DR   KEGG; xla:379557; -.
DR   CTD; 379557; -.
DR   Xenbase; XB-GENE-6255472; lamtor3.L.
DR   OMA; GAEDCNT; -.
DR   OrthoDB; 1525606at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379557; Expressed in heart and 20 other tissues.
DR   GO; GO:0071986; C:Ragulator complex; ISS:UniProtKB.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:GOC.
DR   InterPro; IPR015019; LAMTOR3.
DR   PANTHER; PTHR13378; PTHR13378; 1.
DR   Pfam; PF08923; MAPKK1_Int; 1.
DR   SMART; SM01278; MAPKK1_Int; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Membrane; Reference proteome.
FT   CHAIN           1..123
FT                   /note="Ragulator complex protein LAMTOR3-B"
FT                   /id="PRO_0000356166"
SQ   SEQUENCE   123 AA;  13538 MW;  93DBAE4029396DF4 CRC64;
     MAEELKRFLY KKLPSIEGLH AIVVSDRDGV PVIKVANENA PELALRPSFL STFALATDQG
     SKLGLSKNKS IICYYDTCQV VQFNRLPLVV SFIASSDANT GLLLSLNEEL GDLFEELQHA
     VEI