ID   LTV1_DANRE              Reviewed;         469 AA.
AC   Q5U3J8; Q6DRP7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein LTV1 homolog;
GN   Name=ltv1; ORFNames=zgc:103432;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15256591; DOI=10.1073/pnas.0403929101;
RA   Amsterdam A., Nissen R.M., Sun Z., Swindell E.C., Farrington S.,
RA   Hopkins N.;
RT   "Identification of 315 genes essential for early zebrafish development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12792-12797(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LTV1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY648712; AAT68030.1; -; mRNA.
DR   EMBL; BC085516; AAH85516.1; -; mRNA.
DR   AlphaFoldDB; Q5U3J8; -.
DR   STRING; 7955.ENSDARP00000017491; -.
DR   PRIDE; Q5U3J8; -.
DR   ZFIN; ZDB-GENE-040712-1; ltv1.
DR   eggNOG; KOG2637; Eukaryota.
DR   InParanoid; Q5U3J8; -.
DR   PhylomeDB; Q5U3J8; -.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q5U3J8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR007307; Ltv1.
DR   PANTHER; PTHR21531; PTHR21531; 1.
DR   Pfam; PF04180; LTV; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..469
FT                   /note="Protein LTV1 homolog"
FT                   /id="PRO_0000302817"
FT   REGION          88..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          444..467
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        88..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..208
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..329
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        427..442
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        91
FT                   /note="T -> A (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        103
FT                   /note="K -> E (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="S -> G (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        110
FT                   /note="S -> P (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        175
FT                   /note="S -> N (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        184
FT                   /note="E -> GGEDD (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        324
FT                   /note="D -> DE (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        335
FT                   /note="E -> K (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        437
FT                   /note="K -> E (in Ref. 1; AAT68030)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   469 AA;  54209 MW;  9E3A0732CE98F6BA CRC64;
     MPHRKKKSFI NKKNAVSFHL VHRSQKDPLA ADETAPQHVL LPTVRVELEK RKEEQRNFGV
     FFDDDYDYLQ HLRESTQTAE LISAPRVRRD TRLKPADDEE HMKEEDSSVS EASIKLPSSV
     FASEFEEEVG LLNKAAPISG PRLDMDPDIV AALDEDFDFD DPENMLEDDF IIKASDVMGG
     GGGEDDDEWE DTDDDDGEEQ DFDSEAGLSD DEEGGRREFM FADCETKTRF TEYSLTSSVM
     RRNEQLTLLD DRFDEFYKQF DDDEIGALDN AELEGYIEPD SARLEEVIKD YFIQKEKDCQ
     KPDQLGPAEL PSVREEDEED EDADEELETE RMVIEPPAER WDCETIISTY SNLYNRPKLI
     QDPPKPKQIR VSSKSGIPLD VLPKRGLTVK QVERMERIND SDLPRVSTQP RSRDENTEER
     KARKQAIKSE RKERRTKKKA NKLAFKQEKQ MQEKQMVHLR ANVQGMKLS