LTV1_HUMAN
ID LTV1_HUMAN Reviewed; 475 AA.
AC Q96GA3; Q96JX8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Protein LTV1 homolog;
GN Name=LTV1; Synonyms=C6orf93;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 49-475.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-24 AND SER-408, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96GA3; Q13895: BYSL; NbExp=11; IntAct=EBI-2558389, EBI-358049;
CC Q96GA3; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-2558389, EBI-7960826;
CC Q96GA3; P23396: RPS3; NbExp=3; IntAct=EBI-2558389, EBI-351193;
CC -!- SIMILARITY: Belongs to the LTV1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55388.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL049844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW47859.1; -; Genomic_DNA.
DR EMBL; BC009855; AAH09855.1; -; mRNA.
DR EMBL; AK027815; BAB55388.1; ALT_INIT; mRNA.
DR CCDS; CCDS5201.1; -.
DR RefSeq; NP_116249.2; NM_032860.4.
DR PDB; 6G18; EM; 3.60 A; t=1-475.
DR PDB; 6G4S; EM; 4.00 A; t=1-475.
DR PDB; 6G4W; EM; 4.50 A; t=352-369.
DR PDB; 6G51; EM; 4.10 A; t=1-475.
DR PDB; 6G53; EM; 4.50 A; t=1-475.
DR PDBsum; 6G18; -.
DR PDBsum; 6G4S; -.
DR PDBsum; 6G4W; -.
DR PDBsum; 6G51; -.
DR PDBsum; 6G53; -.
DR AlphaFoldDB; Q96GA3; -.
DR SMR; Q96GA3; -.
DR BioGRID; 124379; 206.
DR IntAct; Q96GA3; 56.
DR MINT; Q96GA3; -.
DR STRING; 9606.ENSP00000356548; -.
DR GlyGen; Q96GA3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96GA3; -.
DR PhosphoSitePlus; Q96GA3; -.
DR BioMuta; LTV1; -.
DR DMDM; 74751878; -.
DR EPD; Q96GA3; -.
DR jPOST; Q96GA3; -.
DR MassIVE; Q96GA3; -.
DR MaxQB; Q96GA3; -.
DR PaxDb; Q96GA3; -.
DR PeptideAtlas; Q96GA3; -.
DR PRIDE; Q96GA3; -.
DR ProteomicsDB; 76608; -.
DR Antibodypedia; 33167; 77 antibodies from 15 providers.
DR DNASU; 84946; -.
DR Ensembl; ENST00000367576.6; ENSP00000356548.5; ENSG00000135521.9.
DR GeneID; 84946; -.
DR KEGG; hsa:84946; -.
DR MANE-Select; ENST00000367576.6; ENSP00000356548.5; NM_032860.5; NP_116249.2.
DR UCSC; uc003qjs.4; human.
DR CTD; 84946; -.
DR GeneCards; LTV1; -.
DR HGNC; HGNC:21173; LTV1.
DR HPA; ENSG00000135521; Low tissue specificity.
DR neXtProt; NX_Q96GA3; -.
DR OpenTargets; ENSG00000135521; -.
DR PharmGKB; PA134893631; -.
DR VEuPathDB; HostDB:ENSG00000135521; -.
DR eggNOG; KOG2637; Eukaryota.
DR GeneTree; ENSGT00390000002789; -.
DR HOGENOM; CLU_035718_0_0_1; -.
DR InParanoid; Q96GA3; -.
DR OMA; HPVVMQC; -.
DR OrthoDB; 917248at2759; -.
DR PhylomeDB; Q96GA3; -.
DR TreeFam; TF314845; -.
DR PathwayCommons; Q96GA3; -.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q96GA3; -.
DR BioGRID-ORCS; 84946; 708 hits in 1082 CRISPR screens.
DR ChiTaRS; LTV1; human.
DR GenomeRNAi; 84946; -.
DR Pharos; Q96GA3; Tbio.
DR PRO; PR:Q96GA3; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96GA3; protein.
DR Bgee; ENSG00000135521; Expressed in epithelial cell of pancreas and 183 other tissues.
DR Genevisible; Q96GA3; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR InterPro; IPR007307; Ltv1.
DR PANTHER; PTHR21531; PTHR21531; 1.
DR Pfam; PF04180; LTV; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..475
FT /note="Protein LTV1 homolog"
FT /id="PRO_0000302813"
FT REGION 23..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 418..475
FT /evidence="ECO:0000255"
FT COMPBIAS 179..209
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 248
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NSQ7"
FT MOD_RES 331
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT MOD_RES 408
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
SQ SEQUENCE 475 AA; 54855 MW; 76AB95901C5BF239 CRC64;
MPHRKKKPFI EKKKAVSFHL VHRSQRDPLA ADESAPQRVL LPTQKIDNEE RRAEQRKYGV
FFDDDYDYLQ HLKEPSGPSE LIPSSTFSAH NRREEKEETL VIPSTGIKLP SSVFASEFEE
DVGLLNKAAP VSGPRLDFDP DIVAALDDDF DFDDPDNLLE DDFILQANKA TGEEEGMDIQ
KSENEDDSEW EDVDDEKGDS NDDYDSAGLL SDEDCMSVPG KTHRAIADHL FWSEETKSRF
TEYSMTSSVM RRNEQLTLHD ERFEKFYEQY DDDEIGALDN AELEGSIQVD SNRLQEVLND
YYKEKAENCV KLNTLEPLED QDLPMNELDE SEEEEMITVV LEEAKEKWDC ESICSTYSNL
YNHPQLIKYQ PKPKQIRISS KTGIPLNVLP KKGLTAKQTE RIQMINGSDL PKVSTQPRSK
NESKEDKRAR KQAIKEERKE RRVEKKANKL AFKLEKRRQE KELLNLKKNV EGLKL
