ID   LTV1_SCHPO              Reviewed;         386 AA.
AC   Q10191;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Protein LTV1;
GN   Name=ltv1; ORFNames=SPAC3F10.17;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171; SER-179; SER-244;
RP   SER-245 AND SER-286, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Involved in protein transport. Non-ribosomal factor required
CC       for efficient nuclear export of the ribosomal 40S subunit. May
CC       participate in intracellular sorting of GAP1 out of the endosome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LTV1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA93315.1; -; Genomic_DNA.
DR   PIR; T38718; T38718.
DR   RefSeq; NP_593949.1; NM_001019376.2.
DR   AlphaFoldDB; Q10191; -.
DR   STRING; 4896.SPAC3F10.17.1; -.
DR   iPTMnet; Q10191; -.
DR   SwissPalm; Q10191; -.
DR   MaxQB; Q10191; -.
DR   PaxDb; Q10191; -.
DR   PRIDE; Q10191; -.
DR   EnsemblFungi; SPAC3F10.17.1; SPAC3F10.17.1:pep; SPAC3F10.17.
DR   GeneID; 2541634; -.
DR   KEGG; spo:SPAC3F10.17; -.
DR   PomBase; SPAC3F10.17; ltv1.
DR   VEuPathDB; FungiDB:SPAC3F10.17; -.
DR   eggNOG; KOG2637; Eukaryota.
DR   HOGENOM; CLU_028555_1_0_1; -.
DR   InParanoid; Q10191; -.
DR   OMA; AGKSEWE; -.
DR   PhylomeDB; Q10191; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q10191; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; ISO:PomBase.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; IBA:GO_Central.
DR   GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR   InterPro; IPR007307; Ltv1.
DR   PANTHER; PTHR21531; PTHR21531; 1.
DR   Pfam; PF04180; LTV; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..386
FT                   /note="Protein LTV1"
FT                   /id="PRO_0000116480"
FT   REGION          103..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         171
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         179
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         245
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
FT   MOD_RES         286
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   386 AA;  44480 MW;  63801C1ACD8E5DEE CRC64;
     MGKKKFVNKN KAQTFHLVHR SQRDPQYHDE NATERVLVSA ETLNKTARRL NRQTLDEEYG
     STIRPNEGEA ANYGIYFDDT EYDYMQHLRN IGNEDATWVE APATRKTQDK QKKQQIQLRD
     QPSILPQEVL PSEVELERTY QDQQSVPDAI SGFQPDMDPR LREVLEQLEH SDINDEETSD
     FDEEFEKLVA SGKADESEFY AQPFVEEGEK DYDEAAAAKA GKSEWEIEFE KFKLEQKKQP
     DVASSDGDFS DEPESEERDE VPELVSSSKS KSKTKRKART ALSSVSMSSS ALFRNEGLTL
     LDDRFDKVEE EYTPIKDERE LIDPDQKDVF DLVNDNQFND IMDEFLVSYG PTLGRKKAPS
     RMSNSKKKSS LEELDNVRKM LGRARI