LUC7L_MOUSE
ID LUC7L_MOUSE Reviewed; 371 AA.
AC Q9CYI4; Q8K247; Q9CWM1;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Putative RNA-binding protein Luc7-like 1;
GN Name=Luc7l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Embryonic stem cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May bind to RNA via its Arg/Ser-rich domain.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CYI4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CYI4-2; Sequence=VSP_010216;
CC -!- SIMILARITY: Belongs to the Luc7 family. {ECO:0000305}.
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DR EMBL; AK010539; BAB27015.1; -; mRNA.
DR EMBL; AK017655; BAB30856.1; -; mRNA.
DR EMBL; BC034135; AAH34135.1; -; mRNA.
DR CCDS; CCDS28549.1; -. [Q9CYI4-1]
DR RefSeq; NP_080157.1; NM_025881.3.
DR RefSeq; NP_082466.2; NM_028190.3. [Q9CYI4-1]
DR RefSeq; XP_017173104.1; XM_017317615.1. [Q9CYI4-2]
DR AlphaFoldDB; Q9CYI4; -.
DR SMR; Q9CYI4; -.
DR BioGRID; 211851; 5.
DR STRING; 10090.ENSMUSP00000110627; -.
DR iPTMnet; Q9CYI4; -.
DR PhosphoSitePlus; Q9CYI4; -.
DR EPD; Q9CYI4; -.
DR jPOST; Q9CYI4; -.
DR MaxQB; Q9CYI4; -.
DR PaxDb; Q9CYI4; -.
DR PeptideAtlas; Q9CYI4; -.
DR PRIDE; Q9CYI4; -.
DR ProteomicsDB; 292130; -. [Q9CYI4-1]
DR ProteomicsDB; 292131; -. [Q9CYI4-2]
DR Antibodypedia; 22529; 210 antibodies from 23 providers.
DR DNASU; 66978; -.
DR Ensembl; ENSMUST00000114976; ENSMUSP00000110627; ENSMUSG00000024188. [Q9CYI4-1]
DR GeneID; 66978; -.
DR KEGG; mmu:66978; -.
DR UCSC; uc008bdy.2; mouse. [Q9CYI4-1]
DR CTD; 55692; -.
DR MGI; MGI:1914228; Luc7l.
DR VEuPathDB; HostDB:ENSMUSG00000024188; -.
DR eggNOG; KOG0796; Eukaryota.
DR GeneTree; ENSGT00950000183213; -.
DR InParanoid; Q9CYI4; -.
DR OMA; LGYVKMR; -.
DR PhylomeDB; Q9CYI4; -.
DR TreeFam; TF317607; -.
DR BioGRID-ORCS; 66978; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Luc7l; mouse.
DR PRO; PR:Q9CYI4; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CYI4; protein.
DR Bgee; ENSMUSG00000024188; Expressed in retinal neural layer and 255 other tissues.
DR ExpressionAtlas; Q9CYI4; baseline and differential.
DR Genevisible; Q9CYI4; MM.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0050733; F:RS domain binding; IPI:MGI.
DR GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR GO; GO:0045843; P:negative regulation of striated muscle tissue development; IDA:MGI.
DR InterPro; IPR004882; Luc7-rel.
DR PANTHER; PTHR12375; PTHR12375; 1.
DR Pfam; PF03194; LUC7; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..371
FT /note="Putative RNA-binding protein Luc7-like 1"
FT /id="PRO_0000187281"
FT REGION 232..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..177
FT /evidence="ECO:0000255"
FT COILED 220..256
FT /evidence="ECO:0000255"
FT COMPBIAS 232..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..321
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ29"
FT MOD_RES 363
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ29"
FT VAR_SEQ 1..53
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_010216"
FT CONFLICT 213
FT /note="K -> E (in Ref. 1; BAB30856)"
FT /evidence="ECO:0000305"
FT CONFLICT 224..226
FT /note="KLD -> SLI (in Ref. 1; BAB30856)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="K -> R (in Ref. 1; BAB30856)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 43934 MW; D63AC7111F855F4F CRC64;
MSAQAQMRAL LDQLMGTARD GDETRQRVKF TDDRVCKSHL LDCCPHDILA GTRMDLGECT
KIHDLALRAD YEIASKERDL FFELDAMDHL ESFIAECDRR TELAKKRLAE TQEEISAEVS
AKAEKVHELN EEIGKLLAKA EQLGAEGNVD ESQKILMEVE KVRAKKKEAE EEYRNSMPAS
SFQQQKLRVC EVCSAYLGLH DNDRRLADHF GGKLHLGFIQ IREKLDQLRK TVAEKQEKRN
QDRLRRREER EREERLGRRS GSRTRDRRRS RSRDRRRRRS RSTSRERRKF SRSRSRDRYR
RHRSRSRSHS RGHRRASRDR STKYKFSRER SLREESWEYG RNERGPTDWR LENSNGKTAS
RRSEEKEAGE I
