LUC7_SCHPO
ID LUC7_SCHPO Reviewed; 264 AA.
AC Q9USM4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=U1 snRNP-associated protein usp106;
DE AltName: Full=Protein luc7;
GN Name=usp106; Synonyms=luc7; ORFNames=SPCC16A11.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP IDENTIFICATION IN THE U1 SNRNP COMPLEX, AND FUNCTION.
RX PubMed=17264129; DOI=10.1093/nar/gkl1144;
RA Newo A.N.S., Luetzelberger M., Bottner C.A., Wehland J., Wissing J.,
RA Jaensch L., Kaeufer N.F.;
RT "Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals
RT three essential organism-specific proteins.";
RL Nucleic Acids Res. 35:1391-1401(2007).
CC -!- FUNCTION: Component of the U1 snRNP particle, which recognizes and
CC binds the 5'-splice site of pre-mRNA. Together with other non-snRNP
CC factors, U1 snRNP forms the spliceosomal commitment complex, that
CC targets pre-mRNA to the splicing pathway.
CC {ECO:0000269|PubMed:17264129}.
CC -!- SUBUNIT: Component of the U1 snRNP particle, a subcomplex of the
CC spliceosome. {ECO:0000269|PubMed:17264129}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the Luc7 family. {ECO:0000305}.
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DR EMBL; CU329672; CAB53085.1; -; Genomic_DNA.
DR PIR; T41086; T41086.
DR RefSeq; NP_588000.1; NM_001022991.2.
DR AlphaFoldDB; Q9USM4; -.
DR SMR; Q9USM4; -.
DR BioGRID; 275628; 16.
DR IntAct; Q9USM4; 1.
DR STRING; 4896.SPCC16A11.13.1; -.
DR MaxQB; Q9USM4; -.
DR PaxDb; Q9USM4; -.
DR EnsemblFungi; SPCC16A11.13.1; SPCC16A11.13.1:pep; SPCC16A11.13.
DR GeneID; 2539055; -.
DR KEGG; spo:SPCC16A11.13; -.
DR PomBase; SPCC16A11.13; -.
DR VEuPathDB; FungiDB:SPCC16A11.13; -.
DR eggNOG; KOG0796; Eukaryota.
DR HOGENOM; CLU_030397_1_0_1; -.
DR InParanoid; Q9USM4; -.
DR OMA; LGYVKMR; -.
DR PhylomeDB; Q9USM4; -.
DR PRO; PR:Q9USM4; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005685; C:U1 snRNP; IDA:PomBase.
DR GO; GO:0071004; C:U2-type prespliceosome; ISO:PomBase.
DR GO; GO:0003729; F:mRNA binding; ISO:PomBase.
DR GO; GO:0000395; P:mRNA 5'-splice site recognition; IC:PomBase.
DR GO; GO:0006376; P:mRNA splice site selection; IBA:GO_Central.
DR InterPro; IPR004882; Luc7-rel.
DR PANTHER; PTHR12375; PTHR12375; 1.
DR Pfam; PF03194; LUC7; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Ribonucleoprotein; Spliceosome.
FT CHAIN 1..264
FT /note="U1 snRNP-associated protein usp106"
FT /id="PRO_0000362156"
FT REGION 233..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..126
FT /evidence="ECO:0000255"
FT COMPBIAS 233..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 30937 MW; DC74E10B3AA84F2F CRC64;
MAAEQRKIIE QLMGSNLSNF TSRGLVHFTD RKVCRSFLCG ICPHDIFTNT KMDLGPCPKI
HSDKLKSDYE RASYSHDYGY EWDYLEDLER HVDDCNKRID IAEARREKTK EEEERIDELM
RDIIHTDHSI EVIITEMEAL AKRKLVNDAV KHFIELNRLK TYRKELYDEV ISMNEIPSQA
STTHQKLQVC DICSAYLSRL DNDRRLADHF SGKMHLGYAM LRNIARDLRA QLEDREKSRD
KKDGEKQRDN LASFEDKIST SFVA
