LUKL1_STAA8
ID LUKL1_STAA8 Reviewed; 338 AA.
AC Q2FWP0;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Uncharacterized leukocidin-like protein 1;
DE Flags: Precursor;
GN OrderedLocusNames=SAOUHSC_02241;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND INDUCTION.
RC STRAIN=RN4220;
RX PubMed=20472795; DOI=10.1128/jb.01452-09;
RA Sibbald M.J., Winter T., van der Kooi-Pol M.M., Buist G., Tsompanidou E.,
RA Bosma T., Schafer T., Ohlsen K., Hecker M., Antelmann H., Engelmann S.,
RA van Dijl J.M.;
RT "Synthetic effects of secG and secY2 mutations on exoproteome biogenesis in
RT Staphylococcus aureus.";
RL J. Bacteriol. 192:3788-3800(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20472795}.
CC -!- INDUCTION: Less protein is secreted in a secG or double secG/secY2
CC mutant (at protein level). {ECO:0000269|PubMed:20472795}.
CC -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR EMBL; CP000253; ABD31282.1; -; Genomic_DNA.
DR RefSeq; WP_000595324.1; NZ_LS483365.1.
DR RefSeq; YP_500725.1; NC_007795.1.
DR PDB; 5K59; X-ray; 2.84 A; A/B=30-338.
DR PDB; 6RHV; X-ray; 2.29 A; G=30-338.
DR PDB; 6RHW; X-ray; 2.75 A; G=30-338.
DR PDBsum; 5K59; -.
DR PDBsum; 6RHV; -.
DR PDBsum; 6RHW; -.
DR AlphaFoldDB; Q2FWP0; -.
DR SMR; Q2FWP0; -.
DR STRING; 1280.SAXN108_2109; -.
DR ABCD; Q2FWP0; 4 sequenced antibodies.
DR EnsemblBacteria; ABD31282; ABD31282; SAOUHSC_02241.
DR GeneID; 3919663; -.
DR KEGG; sao:SAOUHSC_02241; -.
DR PATRIC; fig|93061.5.peg.2035; -.
DR eggNOG; ENOG50348U0; Bacteria.
DR HOGENOM; CLU_055394_0_1_9; -.
DR OMA; EPNGYWN; -.
DR PRO; PR:Q2FWP0; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR InterPro; IPR003963; Bi-component_toxin_staph.
DR InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR Pfam; PF07968; Leukocidin; 1.
DR PRINTS; PR01468; BICOMPNTOXIN.
DR SUPFAM; SSF56959; SSF56959; 1.
DR TIGRFAMs; TIGR01002; hlyII; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..338
FT /note="Uncharacterized leukocidin-like protein 1"
FT /id="PRO_0000298637"
FT STRAND 48..58
FT /evidence="ECO:0007829|PDB:6RHV"
FT TURN 59..62
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 63..73
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 78..86
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 89..91
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 95..97
FT /evidence="ECO:0007829|PDB:6RHW"
FT STRAND 102..119
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 122..133
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:5K59"
FT STRAND 141..151
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 154..157
FT /evidence="ECO:0007829|PDB:5K59"
FT STRAND 162..164
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 166..186
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 192..201
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 204..206
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 209..211
FT /evidence="ECO:0007829|PDB:6RHV"
FT TURN 215..218
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 221..224
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 227..230
FT /evidence="ECO:0007829|PDB:6RHW"
FT HELIX 234..236
FT /evidence="ECO:0007829|PDB:5K59"
FT HELIX 238..240
FT /evidence="ECO:0007829|PDB:6RHV"
FT HELIX 245..247
FT /evidence="ECO:0007829|PDB:6RHV"
FT HELIX 250..253
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 260..267
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 272..294
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 297..320
FT /evidence="ECO:0007829|PDB:6RHV"
FT TURN 321..324
FT /evidence="ECO:0007829|PDB:6RHV"
FT STRAND 325..331
FT /evidence="ECO:0007829|PDB:6RHV"
SQ SEQUENCE 338 AA; 38686 MW; 47B194756D50C33E CRC64;
MIKQLCKNIT ICTLALSTTF TVLPATSFAK INSEIKQVSE KNLDGDTKMY TRTATTSDSQ
KNITQSLQFN FLTEPNYDKE TVFIKAKGTI GSGLRILDPN GYWNSTLRWP GSYSVSIQNV
DDNNNTNVTD FAPKNQDESR EVKYTYGYKT GGDFSINRGG LTGNITKESN YSETISYQQP
SYRTLLDQST SHKGVGWKVE AHLINNMGHD HTRQLTNDSD NRTKSEIFSL TRNGNLWAKD
NFTPKDKMPV TVSEGFNPEF LAVMSHDKKD KGKSQFVVHY KRSMDEFKID WNRHGFWGYW
SGENHVDKKE EKLSALYEVD WKTHNVKFVK VLNDNEKK
