ID   LUKL1_STAAC             Reviewed;         338 AA.
AC   P21224; Q5HEI0;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 3.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Uncharacterized leukocidin-like protein 1;
DE   Flags: Precursor;
GN   OrderedLocusNames=SACOL2004;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 272-338.
RX   PubMed=2726469; DOI=10.1093/nar/17.8.3305;
RA   Projan S.J., Kornblum J., Kreiswirth B., Moghazeh S.L., Eisner W.,
RA   Novick R.P.;
RT   "Nucleotide sequence: the beta-hemolysin gene of Staphylococcus aureus.";
RL   Nucleic Acids Res. 17:3305-3305(1989).
RN   [3]
RP   INDUCTION DURING ANAEROBIC GROWTH.
RX   PubMed=17384184; DOI=10.1128/jb.00081-07;
RA   Fuchs S., Pane-Farre J., Kohler C., Hecker M., Engelmann S.;
RT   "Anaerobic gene expression in Staphylococcus aureus.";
RL   J. Bacteriol. 189:4275-4289(2007).
CC   -!- INDUCTION: Up-regulated during anaerobic growth.
CC       {ECO:0000269|PubMed:17384184}.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW36973.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000046; AAW36973.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X13404; CAA31770.1; -; Genomic_DNA.
DR   PIR; S15767; S15767.
DR   RefSeq; WP_000595324.1; NC_002951.2.
DR   AlphaFoldDB; P21224; -.
DR   SASBDB; P21224; -.
DR   SMR; P21224; -.
DR   ABCD; P21224; 5 sequenced antibodies.
DR   EnsemblBacteria; AAW36973; AAW36973; SACOL2004.
DR   KEGG; sac:SACOL2004; -.
DR   HOGENOM; CLU_055394_1_0_9; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
DR   TIGRFAMs; TIGR01002; hlyII; 1.
PE   2: Evidence at transcript level;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..338
FT                   /note="Uncharacterized leukocidin-like protein 1"
FT                   /id="PRO_0000066076"
FT   CONFLICT        272..280
FT                   /note="GKSQFVVHY -> SISMRHVRV (in Ref. 2; CAA31770)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   338 AA;  38686 MW;  47B194756D50C33E CRC64;
     MIKQLCKNIT ICTLALSTTF TVLPATSFAK INSEIKQVSE KNLDGDTKMY TRTATTSDSQ
     KNITQSLQFN FLTEPNYDKE TVFIKAKGTI GSGLRILDPN GYWNSTLRWP GSYSVSIQNV
     DDNNNTNVTD FAPKNQDESR EVKYTYGYKT GGDFSINRGG LTGNITKESN YSETISYQQP
     SYRTLLDQST SHKGVGWKVE AHLINNMGHD HTRQLTNDSD NRTKSEIFSL TRNGNLWAKD
     NFTPKDKMPV TVSEGFNPEF LAVMSHDKKD KGKSQFVVHY KRSMDEFKID WNRHGFWGYW
     SGENHVDKKE EKLSALYEVD WKTHNVKFVK VLNDNEKK