ID   LUKL1_STAAR             Reviewed;         339 AA.
AC   Q6GF50;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Uncharacterized leukocidin-like protein 1;
DE   Flags: Precursor;
GN   OrderedLocusNames=SAR2107;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41089.1; -; Genomic_DNA.
DR   RefSeq; WP_000595617.1; NC_002952.2.
DR   AlphaFoldDB; Q6GF50; -.
DR   SMR; Q6GF50; -.
DR   KEGG; sar:SAR2107; -.
DR   HOGENOM; CLU_055394_0_1_9; -.
DR   OMA; EPNGYWN; -.
DR   OrthoDB; 574603at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
DR   TIGRFAMs; TIGR01002; hlyII; 1.
PE   3: Inferred from homology;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..339
FT                   /note="Uncharacterized leukocidin-like protein 1"
FT                   /id="PRO_0000298632"
SQ   SEQUENCE   339 AA;  38674 MW;  049B5AF60CCE9CB5 CRC64;
     MIKQVCKNIT ICSLALSTAL TVFPASSYAE IKSKITTVSE KNLDGDTKMY TRTATTSDTE
     KKISQSLQFN FLTEPNYDKE TVFIKAKGTI GSGLKILNPN GYWNSTLRWP GSYSVSIQNV
     DDNNNSTNVT DFAPKNQDES REVKYTYGYK TGGDFSINRG GLTGNITKEK NYSETISYQQ
     PSYRTLIDQP TTNKGVAWKV EAHSINNMGH DHTRQLTNDS DDRVKSEIFS LTRNGNLWAK
     DNFTPKNKMP VTVSEGFNPE FLAVMSHDKN DKGKSRFIVH YKRSMDDFKL DWNKHGFWGY
     WSGENHVDQK EEKLSALYEV DWKTHDVKLI KTINDKEQK