ID   LUKL2_STAA8             Reviewed;         351 AA.
AC   Q2FWN9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Uncharacterized leukocidin-like protein 2;
DE   Flags: Precursor;
GN   OrderedLocusNames=SAOUHSC_02243;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31283.1; -; Genomic_DNA.
DR   RefSeq; WP_000791407.1; NZ_LS483365.1.
DR   RefSeq; YP_500726.1; NC_007795.1.
DR   PDB; 5K59; X-ray; 2.84 A; C/D=33-351.
DR   PDB; 6RHV; X-ray; 2.29 A; H=28-351.
DR   PDB; 6RHW; X-ray; 2.75 A; H=28-351.
DR   PDBsum; 5K59; -.
DR   PDBsum; 6RHV; -.
DR   PDBsum; 6RHW; -.
DR   AlphaFoldDB; Q2FWN9; -.
DR   SMR; Q2FWN9; -.
DR   STRING; 1280.SAXN108_2110; -.
DR   ABCD; Q2FWN9; 4 sequenced antibodies.
DR   EnsemblBacteria; ABD31283; ABD31283; SAOUHSC_02243.
DR   GeneID; 3919664; -.
DR   KEGG; sao:SAOUHSC_02243; -.
DR   PATRIC; fig|93061.5.peg.2036; -.
DR   eggNOG; ENOG5030531; Bacteria.
DR   HOGENOM; CLU_865755_0_0_9; -.
DR   OMA; HWSVVAN; -.
DR   PRO; PR:Q2FWN9; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..351
FT                   /note="Uncharacterized leukocidin-like protein 2"
FT                   /id="PRO_0000298646"
FT   REGION          27..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          69..82
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   TURN            83..86
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          87..97
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          101..115
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          119..122
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          126..128
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          130..146
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          150..157
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          163..176
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          179..182
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          187..197
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          202..207
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          213..222
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          224..227
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          230..233
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   TURN            237..240
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   HELIX           252..255
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   HELIX           259..261
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   HELIX           264..267
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          274..281
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          286..302
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          305..307
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          312..329
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   TURN            330..333
FT                   /evidence="ECO:0007829|PDB:6RHV"
FT   STRAND          334..345
FT                   /evidence="ECO:0007829|PDB:6RHV"
SQ   SEQUENCE   351 AA;  40434 MW;  B562DA10D8C9DE00 CRC64;
     MKNKKRVLIA SSLSCAILLL SAATTQANSA HKDSQDQNKK EHVDKSQQKD KRNVTNKDKN
     STAPDDIGKN GKITKRTETV YDEKTNILQN LQFDFIDDPT YDKNVLLVKK QGSIHSNLKF
     ESHKEEKNSN WLKYPSEYHV DFQVKRNRKT EILDQLPKNK ISTAKVDSTF SYSSGGKFDS
     TKGIGRTSSN SYSKTISYNQ QNYDTIASGK NNNWHVHWSV IANDLKYGGE VKNRNDELLF
     YRNTRIATVE NPELSFASKY RYPALVRSGF NPEFLTYLSN EKSNEKTQFE VTYTRNQDIL
     KNRPGIHYAP PILEKNKDGQ RLIVTYEVDW KNKTVKVVDK YSDDNKPYKE G