ID   LUKL2_STAAC             Reviewed;         351 AA.
AC   Q5HEH9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Uncharacterized leukocidin-like protein 2;
DE   Flags: Precursor;
GN   OrderedLocusNames=SACOL2006;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
RN   [2]
RP   INDUCTION DURING ANAEROBIC GROWTH.
RX   PubMed=17384184; DOI=10.1128/jb.00081-07;
RA   Fuchs S., Pane-Farre J., Kohler C., Hecker M., Engelmann S.;
RT   "Anaerobic gene expression in Staphylococcus aureus.";
RL   J. Bacteriol. 189:4275-4289(2007).
CC   -!- INDUCTION: Up-regulated during anaerobic growth.
CC       {ECO:0000269|PubMed:17384184}.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW36974.1; -; Genomic_DNA.
DR   RefSeq; WP_000791407.1; NC_002951.2.
DR   AlphaFoldDB; Q5HEH9; -.
DR   SASBDB; Q5HEH9; -.
DR   SMR; Q5HEH9; -.
DR   ABCD; Q5HEH9; 4 sequenced antibodies.
DR   EnsemblBacteria; AAW36974; AAW36974; SACOL2006.
DR   KEGG; sac:SACOL2006; -.
DR   HOGENOM; CLU_865755_0_0_9; -.
DR   OMA; HWSVVAN; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
PE   2: Evidence at transcript level;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..351
FT                   /note="Uncharacterized leukocidin-like protein 2"
FT                   /id="PRO_0000298640"
FT   REGION          27..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  40434 MW;  B562DA10D8C9DE00 CRC64;
     MKNKKRVLIA SSLSCAILLL SAATTQANSA HKDSQDQNKK EHVDKSQQKD KRNVTNKDKN
     STAPDDIGKN GKITKRTETV YDEKTNILQN LQFDFIDDPT YDKNVLLVKK QGSIHSNLKF
     ESHKEEKNSN WLKYPSEYHV DFQVKRNRKT EILDQLPKNK ISTAKVDSTF SYSSGGKFDS
     TKGIGRTSSN SYSKTISYNQ QNYDTIASGK NNNWHVHWSV IANDLKYGGE VKNRNDELLF
     YRNTRIATVE NPELSFASKY RYPALVRSGF NPEFLTYLSN EKSNEKTQFE VTYTRNQDIL
     KNRPGIHYAP PILEKNKDGQ RLIVTYEVDW KNKTVKVVDK YSDDNKPYKE G