ID   LUKL2_STAAR             Reviewed;         351 AA.
AC   Q6GF49;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Uncharacterized leukocidin-like protein 2;
DE   Flags: Precursor;
GN   OrderedLocusNames=SAR2108;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG41090.1; -; Genomic_DNA.
DR   RefSeq; WP_000791402.1; NC_002952.2.
DR   AlphaFoldDB; Q6GF49; -.
DR   SMR; Q6GF49; -.
DR   KEGG; sar:SAR2108; -.
DR   HOGENOM; CLU_865755_0_0_9; -.
DR   OMA; HWSVVAN; -.
DR   OrthoDB; 712156at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
PE   3: Inferred from homology;
KW   Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..351
FT                   /note="Uncharacterized leukocidin-like protein 2"
FT                   /id="PRO_0000298641"
FT   REGION          26..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  40503 MW;  782C031898561D6E CRC64;
     MKNKKRVFIA SSLSCVLLLL SAANTEANSA NKDSQDQTKK EHVDKAQQKE KRNVNDKDKN
     TPGPDDIGKN GKVTKRTVSE YDKETNILQN LQFDFIDDPT YDKNVLLVKK QGSIHSNLKF
     ESHRNETNAS WLKYPSEYHV DFQVQRNPKT EILDQLPKNK ISTAKVDSTF SYSLGGKFDS
     TKGIGRTSSN SYSKSISYNQ QNYDTIASGK NNNRHVHWSV VANDLKYGNE IKNRNDEFLF
     YRNTRLSTVE NPELSFASKY RYPALVRSGF NPEFLTYISN EKSNEKTRFE VTYTRNQDIL
     KNKPGIHYGQ PILEQNKDGQ RFIVVYEVDW KNKTVKVVEK YSDQNKPYKE G