ID   LUKL2_STAAS             Reviewed;         350 AA.
AC   Q6G7T7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Uncharacterized leukocidin-like protein 2;
DE   Flags: Precursor;
GN   OrderedLocusNames=SAS1925;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG43731.1; -; Genomic_DNA.
DR   RefSeq; WP_000791417.1; NC_002953.3.
DR   AlphaFoldDB; Q6G7T7; -.
DR   SMR; Q6G7T7; -.
DR   KEGG; sas:SAS1925; -.
DR   HOGENOM; CLU_865755_0_0_9; -.
DR   OMA; HWSVVAN; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0051715; P:cytolysis in another organism; IEA:InterPro.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
PE   3: Inferred from homology;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..350
FT                   /note="Uncharacterized leukocidin-like protein 2"
FT                   /id="PRO_0000298642"
FT   REGION          28..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   350 AA;  40318 MW;  28D59BC8275247A9 CRC64;
     MKNKKRVLIA SSLSCAILLL SAATTQANSA HKDSQDQNKK EHVDKSQQKE KRNVTNKDKN
     STVPDDIGKN GKITKRTETV YDEKTNILQN LQFDFIDDPT YDKNVLLVKK QGSIHSNLKF
     ESHKEEKNSN WLKYPSEYHV DFQVKRNPKT EILDQLPKNK ISTAKVDSTF SYSSGGKFDS
     TKGIGRTSSN SYSKTISYNQ QNYDTIASGK NNNWHVHWSV IANDLKYGGE VKNRNDELLF
     YRNTRIATVE NPELSFASKY RYPALVRSGF NPEFLTYLSN EKSNEKTQFE VTYTRNQDIL
     KNRPGIHYAP PILEKNKEGQ RLIVTYEVDW KNKTVKVVDK YSDNKSFREG