ID   LUKS_STAAU              Reviewed;         315 AA.
AC   P31716;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Leukocidin-S subunit;
DE   Flags: Precursor;
GN   Name=lukS;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 30-79.
RC   STRAIN=NO.4;
RX   PubMed=1958181; DOI=10.1016/s0006-291x(05)81392-0;
RA   Rahman A., Izaki K., Kato I., Kamio Y.;
RT   "Nucleotide sequence of leukocidin S-component gene (lukS) from methicillin
RT   resistant Staphylococcus aureus.";
RL   Biochem. Biophys. Res. Commun. 181:138-144(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MRSA NO. 4;
RX   PubMed=7763998; DOI=10.1271/bbb.57.1234;
RA   Rahman A., Izaki K., Kamio Y.;
RT   "Gamma-hemolysin genes in the same family with lukF and lukS genes in
RT   methicillin resistant Staphylococcus aureus.";
RL   Biosci. Biotechnol. Biochem. 57:1234-1236(1993).
CC   -!- FUNCTION: Leukocidin causes cytotoxic changes in polymorphonuclear
CC       leukocytes.
CC   -!- SUBUNIT: Leukocidin consists of two protein components: F and S.
CC   -!- SIMILARITY: Belongs to the aerolysin family. {ECO:0000305}.
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DR   EMBL; M81346; AAA26654.1; -; Genomic_DNA.
DR   EMBL; S65052; AAC60445.1; -; Genomic_DNA.
DR   PIR; JN0626; JN0626.
DR   AlphaFoldDB; P31716; -.
DR   SMR; P31716; -.
DR   PRO; PR:P31716; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR003963; Bi-component_toxin_staph.
DR   InterPro; IPR016183; Leukocidin/Hemolysin_toxin.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   Pfam; PF07968; Leukocidin; 1.
DR   PRINTS; PR01468; BICOMPNTOXIN.
DR   SUPFAM; SSF56959; SSF56959; 1.
DR   TIGRFAMs; TIGR01002; hlyII; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Direct protein sequencing; Hemolysis; Signal; Toxin; Virulence.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000269|PubMed:1958181"
FT   CHAIN           30..315
FT                   /note="Leukocidin-S subunit"
FT                   /id="PRO_0000018428"
SQ   SEQUENCE   315 AA;  35557 MW;  6F480166DF13AA1E CRC64;
     MLKNKILATT LSVSLLAPLA NPLLENAKAA NDTEDIGKGS DIEIIKRTED KTSNKWGVTQ
     NIQFDFVKDT KYNKDALILK MQGFISSRTT YYNYKKTNHV KAMRWPFQYN IGLKTNDKYV
     SLINYLPKNK IESTNVSQTL GYNIGGNFQS APSLGGNGSF NYSKSISYTQ QNYVSEVEQQ
     NSKSVLWGVK ANSFATESGQ KSAFDSDLFV GYKPHSKDPR DYFVPDSELP PLVQSGFNPS
     FIATVSHEKG SSDTSEFEIT YGRNMDVTHA IKRSTHYGNS YLDGHRVHNA FVNRNYTVKY
     EVNWKTHEIK VKGQN