LUMI_ARATH
ID LUMI_ARATH Reviewed; 953 AA.
AC Q38796; O22771; Q0KG59; Q0KG64; Q0KG74; Q0KG76; Q0KG77; Q0KG78; Q0KG89;
AC Q0KG90; Q0KG91; Q0KG92; Q0KG93; Q0KG94; Q0KG97; Q0WVK1; Q58T20; Q9C5Z9;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Homeobox protein LUMINIDEPENDENS;
GN Name=LD; OrderedLocusNames=At4g02560; ORFNames=T10P11.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Wassilewskija;
RX PubMed=7907507; DOI=10.2307/3869676;
RA Lee I., Aukerman M.J., Gore S.L., Lohman K.N., Michaels S.D., Weaver L.M.,
RA John M.C., Feldmann K.A., Amasino R.M.;
RT "Isolation of LUMINIDEPENDENS: a gene involved in the control of flowering
RT time in Arabidopsis.";
RL Plant Cell 6:75-83(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Lz-0;
RX PubMed=15911588; DOI=10.1534/genetics.104.036533;
RA Werner J.D., Borevitz J.O., Uhlenhaut N.H., Ecker J.R., Chory J.,
RA Weigel D.;
RT "FRIGIDA-independent variation in flowering time of natural Arabidopsis
RT thaliana accessions.";
RL Genetics 170:1197-1207(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS.
RC STRAIN=cv. Akita, cv. Alc-0, cv. All1-1, cv. All2-2, cv. Blh-1, cv. Bui,
RC cv. Bur-0, cv. Cla-1, cv. Cle-1, cv. Cro-1, cv. Ct-1, cv. Cvi-0, cv. Cyr,
RC cv. Dam1, cv. Dam2, cv. Edi-0, cv. Ge-0, cv. Gre-0, cv. Ita-0, cv. Jea,
RC cv. Kn-0, cv. Lac-1, cv. Mar-2, cv. Mar1-2, cv. Mh-1, cv. Mol-1, cv. Mt-0,
RC cv. N13 Konchezero, cv. Nog, cv. Oy-0, cv. Par-2, cv. Pon, cv. Pyl-1,
RC cv. Ran, cv. Rom-1, cv. Sakata, cv. Sha, cv. St-0, cv. Stw-0, cv. Tsu-0,
RC cv. Vou-3, cv. Wha1, and cv. Wha2;
RA Roux F., Camilleri C., Durand S., Le Corre V.;
RT "Sequence variation at the luminidependens gene of Arabidopsis thaliana and
RT association with flowering time.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 294-392.
RC STRAIN=cv. Columbia;
RA Fourmann M., Froger N., Brunel D.;
RT "Amplified consensus gene markers: tools designing for a genetic map of
RT Arabidopsis-known-function genes in Brassica.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP FUNCTION.
RX PubMed=10363371; DOI=10.1046/j.1365-313x.1999.00442.x;
RA Aukerman M.J., Lee I., Weigel D., Amasino R.M.;
RT "The Arabidopsis flowering-time gene LUMINIDEPENDENS is expressed primarily
RT in regions of cell proliferation and encodes a nuclear protein that
RT regulates LEAFY expression.";
RL Plant J. 18:195-203(1999).
RN [9]
RP INTERACTION WITH SUF4.
RX PubMed=17138694; DOI=10.1105/tpc.106.045179;
RA Kim S., Choi K., Park C., Hwang H.J., Lee I.;
RT "SUPPRESSOR OF FRIGIDA4, encoding a C2H2-Type zinc finger protein,
RT represses flowering by transcriptional activation of Arabidopsis FLOWERING
RT LOCUS C.";
RL Plant Cell 18:2985-2998(2006).
CC -!- FUNCTION: Seems to play a role in the regulation of flowering time in
CC the autonomous flowering pathway by repressing FLOWERING LOCUS C
CC expression. {ECO:0000269|PubMed:10363371}.
CC -!- SUBUNIT: Interacts with SUF4. {ECO:0000269|PubMed:17138694}.
CC -!- INTERACTION:
CC Q38796; Q9C5G0: SUF4; NbExp=3; IntAct=EBI-2126221, EBI-2126140;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in shoot apex, root apex, leaf primordia
CC and floral buds.
CC -!- DEVELOPMENTAL STAGE: Accumulates prior to flowering in the vegetative
CC shoot apical meristem and after flowering in floral meristems.
CC -!- DISRUPTION PHENOTYPE: Plants show late flowering phenotype (mutants LD-
CC 1 and LD-3). {ECO:0000269|PubMed:7907507}.
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DR EMBL; U03456; AAA19115.1; -; mRNA.
DR EMBL; AY849995; AAX51265.1; -; Genomic_DNA.
DR EMBL; AM180092; CAJ53827.1; -; Genomic_DNA.
DR EMBL; AM180093; CAJ53828.1; -; Genomic_DNA.
DR EMBL; AM180094; CAJ53829.1; -; Genomic_DNA.
DR EMBL; AM180095; CAJ53830.1; -; Genomic_DNA.
DR EMBL; AM180096; CAJ53831.1; -; Genomic_DNA.
DR EMBL; AM180097; CAJ53832.1; -; Genomic_DNA.
DR EMBL; AM180098; CAJ53833.1; -; Genomic_DNA.
DR EMBL; AM180099; CAJ53834.1; -; Genomic_DNA.
DR EMBL; AM180100; CAJ53835.1; -; Genomic_DNA.
DR EMBL; AM180101; CAJ53836.1; -; Genomic_DNA.
DR EMBL; AM180102; CAJ53837.1; -; Genomic_DNA.
DR EMBL; AM180103; CAJ53838.1; -; Genomic_DNA.
DR EMBL; AM180104; CAJ53839.1; -; Genomic_DNA.
DR EMBL; AM180105; CAJ53840.1; -; Genomic_DNA.
DR EMBL; AM180106; CAJ53841.1; -; Genomic_DNA.
DR EMBL; AM180107; CAJ53842.1; -; Genomic_DNA.
DR EMBL; AM180108; CAJ53843.1; -; Genomic_DNA.
DR EMBL; AM180109; CAJ53844.1; -; Genomic_DNA.
DR EMBL; AM180110; CAJ53845.1; -; Genomic_DNA.
DR EMBL; AM180111; CAJ53846.1; -; Genomic_DNA.
DR EMBL; AM180112; CAJ53847.1; -; Genomic_DNA.
DR EMBL; AM180113; CAJ53848.1; -; Genomic_DNA.
DR EMBL; AM180114; CAJ53849.1; -; Genomic_DNA.
DR EMBL; AM180115; CAJ53850.1; -; Genomic_DNA.
DR EMBL; AM180116; CAJ53851.1; -; Genomic_DNA.
DR EMBL; AM180117; CAJ53852.1; -; Genomic_DNA.
DR EMBL; AM180118; CAJ53853.1; -; Genomic_DNA.
DR EMBL; AM180119; CAJ53854.1; -; Genomic_DNA.
DR EMBL; AM180120; CAJ53855.1; -; Genomic_DNA.
DR EMBL; AM180121; CAJ53856.1; -; Genomic_DNA.
DR EMBL; AM180122; CAJ53857.1; -; Genomic_DNA.
DR EMBL; AM180123; CAJ53858.1; -; Genomic_DNA.
DR EMBL; AM180124; CAJ53859.1; -; Genomic_DNA.
DR EMBL; AM180125; CAJ53860.1; -; Genomic_DNA.
DR EMBL; AM180126; CAJ53861.1; -; Genomic_DNA.
DR EMBL; AM180127; CAJ53862.1; -; Genomic_DNA.
DR EMBL; AM180128; CAJ53863.1; -; Genomic_DNA.
DR EMBL; AM180129; CAJ53864.1; -; Genomic_DNA.
DR EMBL; AM180130; CAJ53865.1; -; Genomic_DNA.
DR EMBL; AM180131; CAJ53866.1; -; Genomic_DNA.
DR EMBL; AM180132; CAJ53867.1; -; Genomic_DNA.
DR EMBL; AM180133; CAJ53868.1; -; Genomic_DNA.
DR EMBL; AM180134; CAJ53869.1; -; Genomic_DNA.
DR EMBL; AC002330; AAC78261.1; -; Genomic_DNA.
DR EMBL; AL161494; CAB80749.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82192.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82193.1; -; Genomic_DNA.
DR EMBL; AK226746; BAE98847.1; -; mRNA.
DR EMBL; AF229402; AAK00674.1; -; Genomic_DNA.
DR PIR; T01093; T01093.
DR RefSeq; NP_001190660.1; NM_001203731.2.
DR RefSeq; NP_192165.1; NM_116490.4.
DR AlphaFoldDB; Q38796; -.
DR SMR; Q38796; -.
DR BioGRID; 13195; 7.
DR IntAct; Q38796; 2.
DR STRING; 3702.AT4G02560.1; -.
DR PaxDb; Q38796; -.
DR PRIDE; Q38796; -.
DR ProteomicsDB; 238784; -.
DR EnsemblPlants; AT4G02560.1; AT4G02560.1; AT4G02560.
DR EnsemblPlants; AT4G02560.2; AT4G02560.2; AT4G02560.
DR GeneID; 827904; -.
DR Gramene; AT4G02560.1; AT4G02560.1; AT4G02560.
DR Gramene; AT4G02560.2; AT4G02560.2; AT4G02560.
DR KEGG; ath:AT4G02560; -.
DR Araport; AT4G02560; -.
DR TAIR; locus:2005532; AT4G02560.
DR eggNOG; ENOG502QSCV; Eukaryota.
DR HOGENOM; CLU_008897_0_0_1; -.
DR InParanoid; Q38796; -.
DR OMA; HAQVIEP; -.
DR OrthoDB; 143242at2759; -.
DR PhylomeDB; Q38796; -.
DR PRO; PR:Q38796; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q38796; baseline and differential.
DR Genevisible; Q38796; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:TAIR.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47676; SSF47676; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Flowering; Homeobox;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..953
FT /note="Homeobox protein LUMINIDEPENDENS"
FT /id="PRO_0000049169"
FT REPEAT 498..502
FT /note="1"
FT REPEAT 507..511
FT /note="2"
FT REPEAT 516..520
FT /note="3"
FT REPEAT 525..529
FT /note="4"
FT REPEAT 534..538
FT /note="5"
FT DNA_BIND 63..123
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 404..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..538
FT /note="5 X 5 AA repeats of Q-P-V-N-G"
FT REGION 606..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 861..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 151
FT /note="T -> S (in strain: cv. Alc-0)"
FT VARIANT 170
FT /note="S -> C (in strain: cv. Ita-0)"
FT VARIANT 329
FT /note="Q -> K (in strain: cv. Cle-1, cv. Cyr, cv. Ge-0, cv.
FT Jea, cv. Kn-0, cv. Lz-0, cv. Mar1-2, cv. Mol-1, cv. Par-2,
FT cv. Pon, cv. Rom-1, cv. St-0, cv. Tsu-0, cv. Vou-3, cv.
FT Wha1 and cv. Wha2)"
FT VARIANT 445
FT /note="Q -> R (in strain: cv. Mar-2)"
FT VARIANT 457
FT /note="A -> C (in strain: cv. Cvi-0)"
FT VARIANT 479
FT /note="P -> A (in strain: cv. Cle-1, cv. Cyr, cv. Ge-0, cv.
FT Jea, cv. Kn-0, cv. Lz-0, cv. Mar1-2, cv. Mol-1, cv. Par-2,
FT cv. Pon, cv. Rom-1, cv. St-0, cv. Tsu-0, cv. Vou-3, cv.
FT Wha1 and cv. Wha2)"
FT VARIANT 512..520
FT /note="Missing (in strain: cv. Cle-1, cv. Cyr, cv. Ge-0,
FT cv. Jea, cv. Kn-0, cv. Lz-0, cv. Mar1-2, cv. Mol-1, cv.
FT Par-2, cv. Pon, cv. Rom-1, cv. St-0, cv. Tsu-0, cv. Vou-3,
FT cv. Wha1 and cv. Wha2)"
FT VARIANT 518
FT /note="V -> G (in strain: cv. Bur-0)"
FT VARIANT 536
FT /note="V -> F (in strain: cv. Cro-1, cv. Lac-1, cv. Sakata
FT and cv. Sha)"
FT VARIANT 542
FT /note="V -> I (in strain: cv. Sakata and cv. Sha)"
FT VARIANT 618
FT /note="R -> Q (in strain: cv. Akita)"
FT VARIANT 761
FT /note="P -> L (in strain: cv. Lac-1)"
FT VARIANT 848
FT /note="Q -> QQ (in strain: cv. Cro-1, cv. Ita-0 and cv.
FT Lac-1)"
FT VARIANT 848
FT /note="Q -> QQQ (in strain: cv. Blh-1)"
FT VARIANT 848
FT /note="Q -> QQQQQ (in strain: cv. Sakata and cv. Sha)"
FT VARIANT 856..857
FT /note="Missing (in strain: cv. Alc-0, cv. Cla-1, cv. Lac-1
FT and cv. Mar-2)"
FT VARIANT 858
FT /note="R -> S (in strain: cv. Kn-0, cv. Lz-0, cv. Par-2 and
FT cv. Pon)"
FT VARIANT 874
FT /note="S -> T (in strain: cv. Cro-1, cv. Sakata and cv.
FT Sha)"
FT VARIANT 879
FT /note="N -> K (in strain: cv. Cro-1)"
FT VARIANT 884
FT /note="H -> R (in strain: cv. Lac-1)"
FT VARIANT 892
FT /note="A -> G (in strain: cv. Cle-1, cv. Cro-1, cv. Cyr,
FT cv. Ge-0, cv. Ita-0, cv. Jea, cv. Kn-0, cv. Lac-1, cv. Lz-
FT 0, cv. Mar1-2, cv. Mol-1, cv. Par-2, cv. Pon, cv. Rom-1,
FT cv. Sakata, cv. Sha, cv. St-0, cv. Tsu-0, cv. Vou-3, cv.
FT Wha1 and cv. Wha2)"
FT VARIANT 923
FT /note="N -> S (in strain: cv. St-0 and cv. Tsu-0)"
FT CONFLICT 320
FT /note="N -> I (in Ref. 7; AAK00674)"
FT /evidence="ECO:0000305"
FT CONFLICT 650
FT /note="T -> S (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 953 AA; 105415 MW; 0DBFF4556190BA77 CRC64;
MDAFKEEIEI GSSVESLMEL LDSQKVLFHS QIDQLQDVVV AQCKLTGVNP LAQEMAAGAL
SIKIGKRPRD LLNPKAVKYL QAVFAIKDAI SKRESREISA LFGITVAQVR EFFVTQKTRV
RKQVRLSREK VVMSNTHALQ DDGVPENNNA TNHVEPVPLN SIHPEACSIS WGEGETVALI
PPEDIPPDIS DSDKYFVENI FSLLRKEETF SGQVKLMEWI MQIQDASVLI WFLSKGGVLI
LTTWLSQAAS EEQTSVLLLI LKVLCHLPLH KASPENMSAI LQSVNGLRFY RISDISNRAK
GLLSRWTKLF AKIQAMKKQN RNSSQIDSQS QLLLKQSIAE IMGDSSNPED ILSLSNGKSE
NVRRIESSQG PKLLLTSADD STKKHMLGSN PSYNKERRKV QMVEQPGQKA AGKSPQTVRI
GTSGRSRPMS ADDIQKAKMR ALYMQSKNSK KDPLPSAIGD SKIVAPEKPL ALHSAKDSPP
IQNNEAKTED TPVLSTVQPV NGFSTIQPVN GPSAVQPVNG PLAVQPVNGP SALQPVNGPS
AVIVPVQADE IKKPSTPPKS ISSKVGVMMK MSSQTILKNC KRKQIDWHVP PGMELDELWR
VAAGGNSKEA DVQRNRNRRE RETTYQSLQT IPLNPKEPWD REMDYDDSLT PEIPSQQPPE
ESLTEPQDSL DERRIAAGAA TTSSSLSSPE PDLELLAALL KNPDLVYALT SGKPSNLAGQ
DMVKLLDVIK TGAPNSSSSS NKQVEERVEV SLPSPTPSTN PGMSGWGQEG IRNPFSRQNQ
VGTAVARSGT QLRVGSMQWH QTNEQSIPRH APSAYSNSIT LAHTEREQQQ YMQPKLHHNL
HFQQQQQQPI STTSYAVREP VGQMGTGTSS SWRSQQSQNS YYSHQENEIA SASQVTSYQG
NSQYMSSNPG YESWSPDNSP SRNQLNMRGQ QQQASRKHDS STHPYWNQNK RWR
