ID   LUM_RABIT               Reviewed;         192 AA.
AC   O46379;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Lumican;
DE   AltName: Full=Keratan sulfate proteoglycan lumican;
DE            Short=KSPG lumican;
DE   Flags: Fragment;
GN   Name=LUM;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white;
RX   PubMed=9822203; DOI=10.1016/s0945-053x(98)90089-0;
RA   Boykiw R.H., Sciore P., Reno C.R., Marchuk L., Frank C., Hart D.A.;
RT   "Altered levels of extracellular matrix molecules mRNA in healing rabbit
RT   ligaments.";
RL   Matrix Biol. 17:371-378(1998).
CC   -!- SUBUNIT: Binds to laminin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- PTM: Sulfated on tyrosine residue(s). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class II subfamily. {ECO:0000305}.
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DR   EMBL; AF020292; AAC39517.1; -; mRNA.
DR   AlphaFoldDB; O46379; -.
DR   SMR; O46379; -.
DR   STRING; 9986.ENSOCUP00000004852; -.
DR   PRIDE; O46379; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; O46379; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030199; P:collagen fibril organization; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027219; Lumican.
DR   PANTHER; PTHR45712:SF6; PTHR45712:SF6; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   PROSITE; PS51450; LRR; 7.
PE   2: Evidence at transcript level;
KW   Extracellular matrix; Glycoprotein; Leucine-rich repeat; Proteoglycan;
KW   Reference proteome; Repeat; Secreted; Sulfation.
FT   CHAIN           <1..>192
FT                   /note="Lumican"
FT                   /id="PRO_0000180085"
FT   REPEAT          1..23
FT                   /note="LRR 1"
FT   REPEAT          26..46
FT                   /note="LRR 2"
FT   REPEAT          47..68
FT                   /note="LRR 3"
FT   REPEAT          69..90
FT                   /note="LRR 4"
FT   REPEAT          94..114
FT                   /note="LRR 5"
FT   REPEAT          115..136
FT                   /note="LRR 6"
FT   REPEAT          139..162
FT                   /note="LRR 7"
FT   REPEAT          164..185
FT                   /note="LRR 8"
FT   REPEAT          186..>192
FT                   /note="LRR 9"
FT   NON_TER         1
FT   NON_TER         192
SQ   SEQUENCE   192 AA;  21833 MW;  60FB9E5AEC58AB01 CRC64;
     LQWLILDHNL LENSKIKGKV FSKLKQLKKL HINHNNLTES VGPLPKSLED LQLTHNKITK
     LGSFDGLLNL TFVHLQHNQL KEDAVSAAFK GLKSLEYLDL SFNQMSKLPS GLPASLLTLY
     LDNNKISDIP DEYFKRFNGL QYLRLSHNEL ADSGIPGNSF NISSLVELDL SYNKLKNIPT
     VNENLENYYL EV