ID   5MP1_DANRE              Reviewed;         421 AA.
AC   Q1LUC1; Q7ZUN5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=eIF5-mimic protein 1 {ECO:0000250|UniProtKB:Q9Y6E2};
DE   AltName: Full=Basic leucine zipper and W2 domain-containing protein 2;
GN   Name=bzw2; Synonyms=5mp1 {ECO:0000250|UniProtKB:Q9Y6E2};
GN   ORFNames=si:ch211-210b19.1, zgc:55580;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Translation initiation regulator which may repress non-AUG
CC       initiated translation and repeat-associated non-AUG (RAN) initiated
CC       translation by acting as a competitive inhibitor of eukaryotic
CC       translation initiation factor 5 (EIF5) function.
CC       {ECO:0000250|UniProtKB:Q9Y6E2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y6E2}.
CC   -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR   EMBL; BX000986; CAK04466.1; -; Genomic_DNA.
DR   EMBL; BX957237; CAK04466.1; JOINED; Genomic_DNA.
DR   EMBL; BX957237; CAK10714.1; -; Genomic_DNA.
DR   EMBL; BX000986; CAK10714.1; JOINED; Genomic_DNA.
DR   EMBL; BX465206; CAK11358.1; -; Genomic_DNA.
DR   EMBL; BC048052; AAH48052.1; -; mRNA.
DR   RefSeq; NP_957212.1; NM_200918.1.
DR   RefSeq; XP_005159662.1; XM_005159605.2.
DR   RefSeq; XP_005159663.1; XM_005159606.1.
DR   RefSeq; XP_005159664.1; XM_005159607.1.
DR   AlphaFoldDB; Q1LUC1; -.
DR   SMR; Q1LUC1; -.
DR   STRING; 7955.ENSDARP00000123337; -.
DR   PaxDb; Q1LUC1; -.
DR   Ensembl; ENSDART00000136213; ENSDARP00000123337; ENSDARG00000035918.
DR   Ensembl; ENSDART00000161882; ENSDARP00000140803; ENSDARG00000035918.
DR   Ensembl; ENSDART00000190949; ENSDARP00000152624; ENSDARG00000035918.
DR   GeneID; 393892; -.
DR   KEGG; dre:393892; -.
DR   CTD; 28969; -.
DR   ZFIN; ZDB-GENE-040426-746; bzw2.
DR   eggNOG; KOG2297; Eukaryota.
DR   GeneTree; ENSGT00390000012561; -.
DR   HOGENOM; CLU_032849_0_1_1; -.
DR   InParanoid; Q1LUC1; -.
DR   OMA; ELIQCIW; -.
DR   OrthoDB; 653740at2759; -.
DR   PhylomeDB; Q1LUC1; -.
DR   TreeFam; TF324313; -.
DR   PRO; PR:Q1LUC1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000035918; Expressed in muscle tissue and 27 other tissues.
DR   ExpressionAtlas; Q1LUC1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   CDD; cd11560; W2_eIF5C_like; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043510; W2_BZW1/2.
DR   InterPro; IPR003307; W2_domain.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Translation regulation.
FT   CHAIN           1..421
FT                   /note="eIF5-mimic protein 1"
FT                   /id="PRO_0000254624"
FT   DOMAIN          250..417
FT                   /note="W2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        141
FT                   /note="F -> L (in Ref. 2; AAH48052)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   421 AA;  48325 MW;  B2E3497222770AAB CRC64;
     MNTGKQQKPV LTGQRFKTRK RDEKEKFEPT VFRDTIVQGL NEAGGDLDAL AKFLDVTGSR
     LDYRRYADTL FDILIAGSML APGGTRIDDA DKTKVTQHCV FNAEENHTTI RSYAQVFNKL
     IRRYKYLEKA FEEEIKKLLL FLKGFTESEQ TKLAMLTGVL LANGTLPPPI LTSLFSDNLV
     KEGISASFAV KMFKAWIAEK DANAVTSALR KANLDKKLLE LFPANKQNVE HFTKFFTEAG
     LKELSDFLRT QQTLGTRKEL QKELQERLSQ QCPIREIVVY VKEEMKKNDL QEQAVIGLLW
     TCLMNAVEWN KKEELVTEQA LKHLKHYAPL LAVFSTQGQS ELVLLLKIQE YCYDNIHFMK
     SFSKIVVLFY KADVVSEEAI MKWYKDAHAA KGKSVFLEQM KKFVEWLQNA EEESESEGEE
     D