LUR1L_HUMAN
ID LUR1L_HUMAN Reviewed; 228 AA.
AC Q8IV03; Q5VZX7; Q8N923; Q8NCG2;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 3.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Leucine rich adaptor protein 1-like;
GN Name=LURAP1L; Synonyms=C9orf150; ORFNames=HYST0841;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-GLY-GLY-55 INS AND
RP GLY-59.
RC TISSUE=Hepatoblastoma;
RX PubMed=15221005; DOI=10.1038/sj.onc.1207782;
RA Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S.,
RA Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S.,
RA Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.;
RT "Expression profiling and differential screening between hepatoblastomas
RT and the corresponding normal livers: identification of high expression of
RT the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.";
RL Oncogene 23:5901-5911(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-GLY-GLY-55 INS AND
RP GLY-59.
RC TISSUE=Chondrocyte, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-GLY-GLY-55 INS AND
RP GLY-59.
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q8IV03; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-12898559, EBI-1166928;
CC Q8IV03; Q3B820: FAM161A; NbExp=3; IntAct=EBI-12898559, EBI-719941;
CC Q8IV03; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12898559, EBI-11022007;
CC Q8IV03; P41219: PRPH; NbExp=3; IntAct=EBI-12898559, EBI-752074;
CC Q8IV03; O00560: SDCBP; NbExp=3; IntAct=EBI-12898559, EBI-727004;
CC Q8IV03; Q9NVR7: TBCCD1; NbExp=3; IntAct=EBI-12898559, EBI-7818932;
CC -!- POLYMORPHISM: The poly-Gly region is polymorphic and the number of Gly
CC varies in the population (from 9 to 12).
CC -!- SEQUENCE CAUTION:
CC Sequence=AK074752; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB073606; BAD38643.1; -; mRNA.
DR EMBL; AK074752; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK095824; BAC04633.1; -; mRNA.
DR EMBL; AL157828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL138753; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036923; AAH36923.1; -; mRNA.
DR CCDS; CCDS6473.1; -.
DR RefSeq; NP_981948.1; NM_203403.1.
DR AlphaFoldDB; Q8IV03; -.
DR BioGRID; 130356; 22.
DR IntAct; Q8IV03; 13.
DR STRING; 9606.ENSP00000321026; -.
DR iPTMnet; Q8IV03; -.
DR PhosphoSitePlus; Q8IV03; -.
DR BioMuta; LURAP1L; -.
DR DMDM; 116241298; -.
DR EPD; Q8IV03; -.
DR jPOST; Q8IV03; -.
DR MassIVE; Q8IV03; -.
DR PeptideAtlas; Q8IV03; -.
DR PRIDE; Q8IV03; -.
DR ProteomicsDB; 70637; -.
DR Antibodypedia; 24398; 88 antibodies from 15 providers.
DR DNASU; 286343; -.
DR Ensembl; ENST00000319264.4; ENSP00000321026.3; ENSG00000153714.6.
DR GeneID; 286343; -.
DR KEGG; hsa:286343; -.
DR MANE-Select; ENST00000319264.4; ENSP00000321026.3; NM_203403.2; NP_981948.1.
DR UCSC; uc003zkw.4; human.
DR CTD; 286343; -.
DR DisGeNET; 286343; -.
DR GeneCards; LURAP1L; -.
DR HGNC; HGNC:31452; LURAP1L.
DR HPA; ENSG00000153714; Low tissue specificity.
DR MIM; 616130; gene.
DR neXtProt; NX_Q8IV03; -.
DR OpenTargets; ENSG00000153714; -.
DR PharmGKB; PA134938789; -.
DR VEuPathDB; HostDB:ENSG00000153714; -.
DR eggNOG; ENOG502QU2C; Eukaryota.
DR GeneTree; ENSGT00530000063790; -.
DR HOGENOM; CLU_106332_1_0_1; -.
DR InParanoid; Q8IV03; -.
DR OrthoDB; 1385244at2759; -.
DR PhylomeDB; Q8IV03; -.
DR TreeFam; TF332089; -.
DR PathwayCommons; Q8IV03; -.
DR SignaLink; Q8IV03; -.
DR BioGRID-ORCS; 286343; 121 hits in 1059 CRISPR screens.
DR ChiTaRS; LURAP1L; human.
DR GenomeRNAi; 286343; -.
DR Pharos; Q8IV03; Tdark.
DR PRO; PR:Q8IV03; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8IV03; protein.
DR Bgee; ENSG00000153714; Expressed in islet of Langerhans and 153 other tissues.
DR Genevisible; Q8IV03; HS.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR InterPro; IPR039499; LURA1/LRA25.
DR InterPro; IPR037443; LURAP1.
DR PANTHER; PTHR33767; PTHR33767; 1.
DR Pfam; PF14854; LURAP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT CHAIN 1..228
FT /note="Leucine rich adaptor protein 1-like"
FT /id="PRO_0000089740"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT VARIANT 47..49
FT /note="Missing (in dbSNP:rs199677889)"
FT /id="VAR_028154"
FT VARIANT 55
FT /note="G -> GGGG"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15221005, ECO:0000269|PubMed:15489334"
FT /id="VAR_085725"
FT VARIANT 59
FT /note="S -> G (in dbSNP:rs3750501)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15221005, ECO:0000269|PubMed:15489334"
FT /id="VAR_028155"
FT CONFLICT 39
FT /note="D -> G (in Ref. 2; BAC04633)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="G -> S (in Ref. 2; AK074752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 228 AA; 24412 MW; D2A81FF0A3E3E062 CRC64;
MEDSPLPDLR DIELKLGRKV PESLVRSLRG EEPVPRERDR DPCGGSGGGG GGGGGCSSSS
SYCSFPPSLS SSSSSSPTSG SPRGSHSSAL ERLETKLHLL RQEMVNLRAT DVRLMRQLLV
INESIESIKW MIEEKATITS RGSSLSGSLC SLLESQSTSL RGSYNSLHDG SDGLDGISVG
SYLDTLADDV PGHQTPSDLD QFSDSSLIED SQALHKRPKL DSEYYCFG
