LUR1L_MOUSE
ID LUR1L_MOUSE Reviewed; 221 AA.
AC Q8K2P1; A2AQI1; Q9D150;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Leucine rich adaptor protein 1-like;
GN Name=Lurap1l; Synonyms=D4Bwg0951e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-221.
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB23088.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL844604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021501; AAH21501.2; -; mRNA.
DR EMBL; BC030404; AAH30404.1; -; mRNA.
DR EMBL; AK003950; BAB23088.1; ALT_FRAME; mRNA.
DR CCDS; CCDS18291.1; -.
DR RefSeq; NP_081097.2; NM_026821.5.
DR AlphaFoldDB; Q8K2P1; -.
DR SMR; Q8K2P1; -.
DR STRING; 10090.ENSMUSP00000062628; -.
DR iPTMnet; Q8K2P1; -.
DR PhosphoSitePlus; Q8K2P1; -.
DR MaxQB; Q8K2P1; -.
DR PaxDb; Q8K2P1; -.
DR PRIDE; Q8K2P1; -.
DR ProteomicsDB; 291968; -.
DR Antibodypedia; 24398; 88 antibodies from 15 providers.
DR Ensembl; ENSMUST00000055922; ENSMUSP00000062628; ENSMUSG00000048706.
DR GeneID; 52829; -.
DR KEGG; mmu:52829; -.
DR UCSC; uc008tjv.1; mouse.
DR CTD; 286343; -.
DR MGI; MGI:106510; Lurap1l.
DR VEuPathDB; HostDB:ENSMUSG00000048706; -.
DR eggNOG; ENOG502QU2C; Eukaryota.
DR GeneTree; ENSGT00530000063790; -.
DR HOGENOM; CLU_106332_1_0_1; -.
DR InParanoid; Q8K2P1; -.
DR OMA; HFLRQEM; -.
DR OrthoDB; 1385244at2759; -.
DR PhylomeDB; Q8K2P1; -.
DR TreeFam; TF332089; -.
DR BioGRID-ORCS; 52829; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Lurap1l; mouse.
DR PRO; PR:Q8K2P1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8K2P1; protein.
DR Bgee; ENSMUSG00000048706; Expressed in left colon and 209 other tissues.
DR Genevisible; Q8K2P1; MM.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IBA:GO_Central.
DR InterPro; IPR039499; LURA1/LRA25.
DR InterPro; IPR037443; LURAP1.
DR PANTHER; PTHR33767; PTHR33767; 1.
DR Pfam; PF14854; LURAP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT CHAIN 1..221
FT /note="Leucine rich adaptor protein 1-like"
FT /id="PRO_0000089741"
FT REGION 24..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8IV03"
FT CONFLICT 12
FT /note="I -> L (in Ref. 3; BAB23088)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="G -> D (in Ref. 3; BAB23088)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 221 AA; 23728 MW; B4EDBA6CF8CCB19F CRC64;
MEDSPLPDLR DIELKLGRKV PESLARSLRG EELAPREGAA DPSGVGGSCS SSSSCSSFAP
SVSSSSSSSP ASGSPRRSHP SALERLETKL HILRQEMVNL RATDVRLMRQ LLLINESIES
IKWMIEEKAT ITSRGSSLSG SLCSLLESQS TSLRGSYNSL HDGSDGLDGI SVGSYLDTLA
DDVPGHQTPS DLDQFSDSSI IEDSQALHKH PKLDSEYYCF G
