ID   LURP1_ARATH             Reviewed;         207 AA.
AC   Q9ZQR8; Q3EC09; Q8VYP1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Protein LURP1;
DE   AltName: Full=Protein LATE UPREGULATED IN RESPONSE TO HYALOPERONOSPORA PARASITICA 1;
GN   Name=LURP1; OrderedLocusNames=At2g14560; ORFNames=T13P21.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RA   Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA   Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA   Shinozaki K.;
RT   "Analysis of multiple occurrences of alternative splicing events in
RT   Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL   DNA Res. 16:155-164(2009).
RN   [6]
RP   INDUCTION BY OOMYCETES, AND DISRUPTION PHENOTYPE.
RX   PubMed=18346188; DOI=10.1111/j.1365-313x.2008.03486.x;
RA   Knoth C., Eulgem T.;
RT   "The oomycete response gene LURP1 is required for defense against
RT   Hyaloperonospora parasitica in Arabidopsis thaliana.";
RL   Plant J. 55:53-64(2008).
CC   -!- FUNCTION: Involved in basal defense against virulent oomycetes. Might
CC       be related to the phospholipid scramblase and tubby-like superfamily of
CC       membrane tethered transcription factors (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ZQR8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ZQR8-2; Sequence=VSP_039830, VSP_039831;
CC   -!- TISSUE SPECIFICITY: Limited to discrete pathogen infection sites in
CC       leaves.
CC   -!- INDUCTION: Up-regulated upon infection by oomycetes, but not by
CC       bacterial or fungal pathogens. {ECO:0000269|PubMed:18346188}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype. Reduced basal and R-
CC       protein-mediated disease resistances. {ECO:0000269|PubMed:18346188}.
CC   -!- SIMILARITY: Belongs to the LOR family. {ECO:0000305}.
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DR   EMBL; AC006067; AAD15461.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06312.1; -; Genomic_DNA.
DR   EMBL; AY070390; AAL49886.1; -; mRNA.
DR   EMBL; BT015680; AAU15179.1; -; mRNA.
DR   EMBL; AK317043; BAH19736.1; -; mRNA.
DR   PIR; F84518; F84518.
DR   RefSeq; NP_179062.1; NM_127019.4. [Q9ZQR8-1]
DR   RefSeq; NP_973456.1; NM_201727.3.
DR   AlphaFoldDB; Q9ZQR8; -.
DR   SMR; Q9ZQR8; -.
DR   STRING; 3702.AT2G14560.1; -.
DR   PaxDb; Q9ZQR8; -.
DR   PRIDE; Q9ZQR8; -.
DR   ProteomicsDB; 238638; -. [Q9ZQR8-1]
DR   EnsemblPlants; AT2G14560.1; AT2G14560.1; AT2G14560. [Q9ZQR8-1]
DR   GeneID; 815943; -.
DR   Gramene; AT2G14560.1; AT2G14560.1; AT2G14560. [Q9ZQR8-1]
DR   KEGG; ath:AT2G14560; -.
DR   Araport; AT2G14560; -.
DR   TAIR; locus:2055250; AT2G14560.
DR   eggNOG; ENOG502QUU9; Eukaryota.
DR   HOGENOM; CLU_063146_5_1_1; -.
DR   InParanoid; Q9ZQR8; -.
DR   OMA; NWSDRSC; -.
DR   PhylomeDB; Q9ZQR8; -.
DR   PRO; PR:Q9ZQR8; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZQR8; baseline and differential.
DR   Genevisible; Q9ZQR8; AT.
DR   GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR   GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR   GO; GO:0009751; P:response to salicylic acid; IEP:TAIR.
DR   Gene3D; 2.40.160.200; -; 1.
DR   InterPro; IPR007612; LOR.
DR   InterPro; IPR038595; LOR_sf.
DR   InterPro; IPR025659; Tubby-like_C.
DR   PANTHER; PTHR31087; PTHR31087; 1.
DR   Pfam; PF04525; LOR; 1.
DR   SUPFAM; SSF54518; SSF54518; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Protein LURP1"
FT                   /id="PRO_0000399232"
FT   VAR_SEQ         151..179
FT                   /note="MCGKQTMRGFFFGKDHFSVTVDKNVDYAF -> VNKLSFLIFVLEDSILHVN
FT                   VYIIYFLN (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:19423640"
FT                   /id="VSP_039830"
FT   VAR_SEQ         180..207
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:19423640"
FT                   /id="VSP_039831"
FT   CONFLICT        73
FT                   /note="G -> E (in Ref. 3; AAL49886)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  22987 MW;  225929451BDC17B8 CRC64;
     MQQPCVIVGS KYCSPNPVGL AIVRKVMKIT DGNFVITSAD GKLLFKVKDP LFSLHGKRIL
     LDCSGAKVLT LRGKMMTMHD RWQVFRGGST EEGALLYTVK RSSMIQLAPK LEVFLANNVE
     EKICDFKVKG AWLDDSCVVY AGDSDTIIAH MCGKQTMRGF FFGKDHFSVT VDKNVDYAFI
     ASLIVILVEI EKAGFITKMT TQMIIGF