LUTB_BACLD
ID LUTB_BACLD Reviewed; 477 AA.
AC Q65EM0; Q62Q37;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Lactate utilization protein B {ECO:0000255|HAMAP-Rule:MF_02103};
GN Name=lutB {ECO:0000255|HAMAP-Rule:MF_02103}; Synonyms=yvfW;
GN OrderedLocusNames=BLi03674, BL03457;
OS Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=279010;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15383718; DOI=10.1159/000079829;
RA Veith B., Herzberg C., Steckel S., Feesche J., Maurer K.H., Ehrenreich P.,
RA Baeumer S., Henne A., Liesegang H., Merkl R., Ehrenreich A., Gottschalk G.;
RT "The complete genome sequence of Bacillus licheniformis DSM13, an organism
RT with great industrial potential.";
RL J. Mol. Microbiol. Biotechnol. 7:204-211(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375
RC / NCTC 10341 / NRRL NRS-1264 / Gibson 46;
RX PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA Rasmussen M.D., Andersen J.T., Joergensen P.L., Larsen T.S., Sorokin A.,
RA Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT "Complete genome sequence of the industrial bacterium Bacillus
RT licheniformis and comparisons with closely related Bacillus species.";
RL Genome Biol. 5:R77.1-R77.12(2004).
CC -!- FUNCTION: Is involved in L-lactate degradation and allows cells to grow
CC with lactate as the sole carbon source. Has probably a role as an
CC electron transporter during oxidation of L-lactate. {ECO:0000255|HAMAP-
CC Rule:MF_02103}.
CC -!- SIMILARITY: Belongs to the LutB/YkgF family. {ECO:0000255|HAMAP-
CC Rule:MF_02103}.
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DR EMBL; AE017333; AAU42494.1; -; Genomic_DNA.
DR EMBL; CP000002; AAU25123.1; -; Genomic_DNA.
DR RefSeq; WP_003185481.1; NC_006322.1.
DR AlphaFoldDB; Q65EM0; -.
DR STRING; 279010.BL03457; -.
DR PRIDE; Q65EM0; -.
DR EnsemblBacteria; AAU25123; AAU25123; BL03457.
DR GeneID; 66214370; -.
DR KEGG; bld:BLi03674; -.
DR KEGG; bli:BL03457; -.
DR eggNOG; COG1139; Bacteria.
DR HOGENOM; CLU_027059_2_0_9; -.
DR OMA; HCPVYDK; -.
DR OrthoDB; 688908at2; -.
DR BioCyc; BLIC279010:BLI_RS18065-MON; -.
DR Proteomes; UP000000606; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019516; P:lactate oxidation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.1060.10; -; 1.
DR Gene3D; 3.40.50.10420; -; 1.
DR HAMAP; MF_02103; LutB; 1.
DR InterPro; IPR004452; 4Fe-4S-bd.
DR InterPro; IPR024569; 4Fe-4S-bd_C.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR024185; FTHF_cligase-like_sf.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR003741; LUD_dom.
DR InterPro; IPR022825; LutB.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR47153; PTHR47153; 1.
DR Pfam; PF11870; DUF3390; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR Pfam; PF02589; LUD_dom; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR00273; TIGR00273; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW Reference proteome; Repeat; Transport.
FT CHAIN 1..477
FT /note="Lactate utilization protein B"
FT /id="PRO_0000383975"
FT DOMAIN 304..334
FT /note="4Fe-4S ferredoxin-type 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT DOMAIN 353..382
FT /note="4Fe-4S ferredoxin-type 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT REGION 433..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 313
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT BINDING 316
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT BINDING 319
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT BINDING 323
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT BINDING 366
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT BINDING 369
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
FT BINDING 373
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_02103"
SQ SEQUENCE 477 AA; 53214 MW; 892CD0FAF8303A03 CRC64;
MAMKIGTQKF KERVSDGLDN EFMRGAVSSA QERLRARRLE AAKELGNWEE WRSLAEEIRQ
HVLENLDYYL EQLAENVAKK GGHVFFAQTA EEATGYIRDV VKKKNGKKIV KSKSMVTEEI
NMNEALESDG CEVVETDLGE YILQIDDHDP PSHIVAPALH KNKEQIRDVF KERIGYRNTE
KPEELVMHAR AVLRKKFLEA DIGITGCNFA IADTGSVSLV TNEGNGRLVT TIPKTQITVM
GMERIVPSFD EFEVLVGMLT RSAVGQRLTS YITALTGPRL PGEADGPEEF HLVIVDNGRS
NILGTEFQSV LQCIRCAACI NVCPVYRHVG GHSYGSIYSG PIGAVLSPLL GGYDDYKELP
YASSLCAACS EACPVKIPLH ELLLKHRQRI VEKEGRAPIS EKLAMKAFGL GTSAPSLYKM
GSKWAPAAMK PFKEDGKITK GPGPLKQWTQ IRDFPAPNKS RFRDWFEDRR KEKGEDK
