ID   LUXM_VIBA3              Reviewed;         395 AA.
AC   B7VQM9; Q000K6;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Acyl-homoserine-lactone synthase LuxM;
DE            Short=AHL synthase LuxM;
DE            EC=2.3.1.184;
GN   Name=luxM; OrderedLocusNames=VS_II0261;
OS   Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=575788;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17122399; DOI=10.1128/aem.02147-06;
RA   Le Roux F., Binesse J., Saulnier D., Mazel D.;
RT   "Construction of a Vibrio splendidus mutant lacking the metalloprotease
RT   gene vsm by use of a novel counterselectable suicide vector.";
RL   Appl. Environ. Microbiol. 73:777-784(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LGP32;
RA   Mazel D., Le Roux F.;
RT   "Vibrio splendidus str. LGP32 complete genome.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the LuxM / VanM family. {ECO:0000305}.
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DR   EMBL; DQ987706; ABJ90449.1; -; Genomic_DNA.
DR   EMBL; FM954973; CAV25639.1; -; Genomic_DNA.
DR   RefSeq; WP_012600240.1; NC_011744.2.
DR   AlphaFoldDB; B7VQM9; -.
DR   STRING; 575788.VS_II0261; -.
DR   EnsemblBacteria; CAV25639; CAV25639; VS_II0261.
DR   KEGG; vsp:VS_II0261; -.
DR   PATRIC; fig|575788.5.peg.255; -.
DR   eggNOG; ENOG5031MRN; Bacteria.
DR   HOGENOM; CLU_053516_0_0_6; -.
DR   OMA; FWCECEI; -.
DR   OrthoDB; 1074258at2; -.
DR   Proteomes; UP000009100; Chromosome 2.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR035304; AHL_synthase.
DR   Pfam; PF17327; AHL_synthase; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..395
FT                   /note="Acyl-homoserine-lactone synthase LuxM"
FT                   /id="PRO_0000379485"
SQ   SEQUENCE   395 AA;  45843 MW;  8535D2C94D71E94F CRC64;
     MELMSSLGSL LASSLPIEKK QHALVELVLH TYQPQQRTAL FKTVTEYRRN QLELLFPEHQ
     AKSDSVMFEV MDYRDLIQRY PNTLSTEVAL LEEAVGQCYI HWLDFWCECE ISAIKAKLPL
     STHALYPMDL PIKDSAYYGV IIDQIENSQL IVQTPTRPQG LPISDAIALS NLEVFIKGEK
     WYEMLPLLHL SQTGKHFILL KHPTDEAFPT LVSSALIQDW SKYETWLSYA PPFCNDKWKY
     SLSRRGYEGL AELHIFTPPA LSKCDSIPEF DNKFQLQLAE MQAVCEILRL TVSGNIQQKV
     YFLYLAQKEM LNLLHQAGYK IGFTIIDQPL ILDFYKAIEP QAYLPLGYCD LNETNLLTYR
     GLWNIELMLK AFNHVNFRDY RRCLRENKNT AWQII