ID   LUXM_VIBC1              Reviewed;         399 AA.
AC   A7MRY3; Q9EVD0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Acyl-homoserine-lactone synthase LuxM;
DE            Short=AHL synthase LuxM;
DE            EC=2.3.1.184;
GN   Name=luxM; Synonyms=luxLM; OrderedLocusNames=VIBHAR_02765;
OS   Vibrio campbellii (strain ATCC BAA-1116).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=2902295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1116 / BB120;
RG   The Vibrio harveyi Genome Sequencing Project;
RA   Bassler B., Clifton S.W., Fulton L., Delehaunty K., Fronick C.,
RA   Harrison M., Markivic C., Fulton R., Tin-Wollam A.-M., Shah N., Pepin K.,
RA   Nash W., Thiruvilangam P., Bhonagiri V., Waters C., Tu K.C., Irgon J.,
RA   Wilson R.K.;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 154-258.
RX   PubMed=11371516; DOI=10.1128/jb.183.12.3537-3547.2001;
RA   Milton D.L., Chalker V.J., Kirke D., Hardman A., Camara M., Williams P.;
RT   "The LuxM homologue VanM from Vibrio anguillarum directs the synthesis of
RT   N-(3-hydroxyhexanoyl)homoserine lactone and N-hexanoylhomoserine lactone.";
RL   J. Bacteriol. 183:3537-3547(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the LuxM / VanM family. {ECO:0000305}.
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DR   EMBL; CP000789; ABU71719.1; -; Genomic_DNA.
DR   EMBL; AF286004; AAG24822.1; -; Genomic_DNA.
DR   RefSeq; WP_012128347.1; NC_022269.1.
DR   AlphaFoldDB; A7MRY3; -.
DR   EnsemblBacteria; ABU71719; ABU71719; VIBHAR_02765.
DR   KEGG; vha:VIBHAR_02765; -.
DR   PATRIC; fig|338187.36.peg.2695; -.
DR   OMA; FWCECEI; -.
DR   OrthoDB; 1074258at2; -.
DR   Proteomes; UP000008152; Chromosome I.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR035304; AHL_synthase.
DR   Pfam; PF17327; AHL_synthase; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..399
FT                   /note="Acyl-homoserine-lactone synthase LuxM"
FT                   /id="PRO_0000379484"
SQ   SEQUENCE   399 AA;  46385 MW;  DD5179FF39AAF307 CRC64;
     MKLMLSLGSL SANSLPIEKK QQVLIDLVIR TYQSHERTEL FKAITEYRKN QLIALFPEHA
     NKSYSIIFEL MDYRDLIERY PSTLSEEATL LEKVVGQCFM HWLDFWCECE IAAIKAKFPL
     KENELPAPQL LFEDSAYYGA LVERVEDTQL MVQIPSHPQA MPLSDAITLS NLELFIQGEK
     WYEMLSLLSL SQVGKHFIVL KHPVQDSCPT LVASALIQNW SVRDTWLSYA PQFSNEQWNY
     CFPSYGYSEF TRLQLFTPST LSKCYSLPEF DNEFKLQLSD TQAVCEVLRL TVSGNAQQKL
     YFLYLAQKEL MSVLHQAGYK IGFTIIEQPF MLNFYRAIDA KAYFHSGYCD LNDDGKQTYR
     GFWNFEMMVK AFSNIDFRGY KRAVRASRKR GSLERDEHV