ID   LUXO_VIBVU              Reviewed;         453 AA.
AC   Q8CWJ5;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Regulatory protein LuxO;
GN   Name=luxO; OrderedLocusNames=VV1_3091;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of different processes depending
CC       on the cell density. Acts together with sigma-54 to repress, perhaps
CC       indirectly, some genes (By similarity). {ECO:0000250}.
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DR   EMBL; AE016795; AAO11414.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q8CWJ5; -.
DR   SMR; Q8CWJ5; -.
DR   EnsemblBacteria; AAO11414; AAO11414; VV1_3091.
DR   KEGG; vvu:VV1_3091; -.
DR   HOGENOM; CLU_000445_0_6_6; -.
DR   OMA; MPISMQV; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Nucleotide-binding; Phosphoprotein; Repressor;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..453
FT                   /note="Regulatory protein LuxO"
FT                   /id="PRO_0000081119"
FT   DOMAIN          1..112
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          133..362
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         161..168
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         224..233
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   MOD_RES         47
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   453 AA;  50515 MW;  6090DAC72958C9D6 CRC64;
     MVEDTASVAA LYRSYLMPLG IDINIVGTGR DAIDSLKHRI PDLILLDLRL PDMTGMDVLH
     AVKASHPDVP IIFMTAHGSI DTAVEAMRHG SQDFLIKPCE ADRLRVTVNN AIRKASKLKN
     DADSAGSQNY QGFIGSSQKM QQVYRTIDSA ASSKASIFIT GESGTGKEVC AEAIHAASRR
     GDKPFIAINC AAIPKDLIES ELFGHVKGAF TGAATDRQGA AELADGGTLF LDELCEMDLD
     LQTKLLRFIQ TGTFQKVGSS KMKSVDVRFV CATNRDPWKE VQEGRFREDL YYRLYVIPLH
     LPPLRERGED VIEIAYSLLG YMSHEEGKNF VRFSQPVIDR FNEYEWPGNV RQLQNVLRNV
     VVLNNGKEIT MEMLPPPLNQ PFERKESVQP DLSELISVRD ICPLWLTEKL AIEQAIKACD
     GNIPRAAGYL DVSPSTIYRK LQAWNEKEEK QKA