ID   LUXP_VIBCH              Reviewed;         364 AA.
AC   Q9KLK6;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Autoinducer 2-binding periplasmic protein LuxP;
DE   Flags: Precursor;
GN   Name=luxP; OrderedLocusNames=VC_A0737;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
RN   [2]
RP   AUTOINDUCER 2 (AI-2) SYNTHESIS IN V.CHOLERAE.
RX   PubMed=9190823; DOI=10.1128/jb.179.12.4043-4045.1997;
RA   Bassler B.L., Greenberg E.P., Stevens A.M.;
RT   "Cross-species induction of luminescence in the quorum-sensing bacterium
RT   Vibrio harveyi.";
RL   J. Bacteriol. 179:4043-4045(1997).
CC   -!- FUNCTION: Binds to the signaling molecule autoinducer 2 (AI-2), a
CC       furanosyl borate diester, (3a-methyl-5,6-dihydrofuro-
CC       [2,3d][1,3,2]dioxaborole-2,2,6,6a-tetraol). This complex then interacts
CC       with the LuxQ sensor protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 2 family.
CC       {ECO:0000305}.
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DR   EMBL; AE003853; AAF96636.1; -; Genomic_DNA.
DR   PIR; D82424; D82424.
DR   RefSeq; NP_233124.1; NC_002506.1.
DR   RefSeq; WP_000823678.1; NZ_LT906615.1.
DR   AlphaFoldDB; Q9KLK6; -.
DR   SMR; Q9KLK6; -.
DR   STRING; 243277.VC_A0737; -.
DR   DNASU; 2611935; -.
DR   EnsemblBacteria; AAF96636; AAF96636; VC_A0737.
DR   KEGG; vch:VC_A0737; -.
DR   PATRIC; fig|243277.26.peg.3360; -.
DR   eggNOG; COG1879; Bacteria.
DR   HOGENOM; CLU_064743_1_0_6; -.
DR   OMA; DDTGIAM; -.
DR   BioCyc; VCHO:VCA0737-MON; -.
DR   Proteomes; UP000000584; Chromosome 2.
DR   GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:UniProt.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR025997; SBP_2_dom.
DR   Pfam; PF13407; Peripla_BP_4; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
PE   3: Inferred from homology;
KW   Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..364
FT                   /note="Autoinducer 2-binding periplasmic protein LuxP"
FT                   /id="PRO_0000031725"
SQ   SEQUENCE   364 AA;  41197 MW;  8E0B9EC0DA2FA9F7 CRC64;
     MKRKLISPLF LIAALFSSTG QADSLKGYWH YDEFLAEFPE QRPISELFAQ TVRDKPSALT
     VAQEQPVIIS VVYPGQQISD YWVRNIKAFE KRMDALGIRY QINQVFTRPN LDTRQQSVSL
     MEALKNKSDY LIFTLDTTRH RKFIEHVLHS SETKLILQNI TTPVKDWQGK QPMMYIGFDH
     EYGAQLLAQY YQAHAPKKPY SVLYFSEGYI SEARGDTFIQ DMNAVHHFPL ASSYYTKATE
     QSGYEATLNI VKNNPEIGFI YACATDVALG AAQALKELNR QDILVNGWGG GSAELEALAK
     GELDVTVMRM NDDTGVAMAE AIKWDLEGKS VPLVYSGDFE VVTKQDSAAR IAELKARAFR
     YSDR