ID   LUXR_VIBHA              Reviewed;         205 AA.
AC   P21308;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=HTH-type transcriptional regulator LuxR;
GN   Name=luxR;
OS   Vibrio harveyi (Beneckea harveyi).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB7;
RX   PubMed=2160932; DOI=10.1128/jb.172.6.2946-2954.1990;
RA   Showalter R.E., Martin M.O., Silverman M.R.;
RT   "Cloning and nucleotide sequence of luxR, a regulatory gene controlling
RT   bioluminescence in Vibrio harveyi.";
RL   J. Bacteriol. 172:2946-2954(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-12.
RX   PubMed=8344950; DOI=10.1016/s0021-9258(19)85475-3;
RA   Swartzman E., Meighen E.A.;
RT   "Purification and characterization of a poly(dA-dT) lux-specific DNA-
RT   binding protein from Vibrio harveyi and identification as LuxR.";
RL   J. Biol. Chem. 268:16706-16716(1993).
CC   -!- FUNCTION: Regulatory protein of bacterial bioluminescence. It probably
CC       binds the autoinducer molecule and potentiates the transcription of the
CC       bioluminescence operon.
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DR   EMBL; M55260; AAA27539.1; -; Genomic_DNA.
DR   PIR; A35386; A35386.
DR   AlphaFoldDB; P21308; -.
DR   SMR; P21308; -.
DR   STRING; 669.AL538_06465; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Direct protein sequencing; DNA-binding; Luminescence;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..205
FT                   /note="HTH-type transcriptional regulator LuxR"
FT                   /id="PRO_0000070605"
FT   DOMAIN          15..75
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
SQ   SEQUENCE   205 AA;  23738 MW;  4F96922CBDE67064 CRC64;
     MDSIAKRPRT RLSPLKRKQQ LMEIALEVFA RRGIGRGGHA DIAEIAQVSV ATVFNYFPTR
     EDLVDEVLNH VVRQFSNFLS DNIDLDIHAR ENIANITNAM IELVSQDCHW LKVWFEWSAS
     TRDEVWPLFV TTNRTNQLLV QNMFIKAIER GEVCDQHEPE HLANLFHGIC YSIFVQANRS
     KSEAELTNLV SAYLDMLCIY NREHH