ID   LUXS_ALIF1              Reviewed;         250 AA.
AC   P35327; Q5DZ01;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Transcriptional activator protein LuxR;
GN   Name=luxR; OrderedLocusNames=VF_A0925;
OS   Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=312309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Gray K.M., Greenberg E.P.;
RT   "Sequencing and analysis of luxR and luxI, the luminescence regulatory
RT   genes from the squid light organ symbiont Vibrio fischeri ES114.";
RL   Mol. Mar. Biol. Biotechnol. 1:414-419(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700601 / ES114;
RX   PubMed=15703294; DOI=10.1073/pnas.0409900102;
RA   Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R.,
RA   Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E.,
RA   Stevens A., Visick K., Whistler C., Greenberg E.P.;
RT   "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with
RT   pathogenic congeners.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005).
CC   -!- FUNCTION: Transcriptional activator of the bioluminescence operon.
CC       Binds to the OHHL autoinducer.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; M96844; AAA27542.1; -; Genomic_DNA.
DR   EMBL; CP000021; AAW87995.1; -; Genomic_DNA.
DR   RefSeq; WP_011263745.1; NC_006841.2.
DR   RefSeq; YP_206883.1; NC_006841.2.
DR   AlphaFoldDB; P35327; -.
DR   SMR; P35327; -.
DR   STRING; 312309.VF_A0925; -.
DR   BindingDB; P35327; -.
DR   ChEMBL; CHEMBL5867; -.
DR   EnsemblBacteria; AAW87995; AAW87995; VF_A0925.
DR   KEGG; vfi:VF_A0925; -.
DR   PATRIC; fig|312309.11.peg.3527; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_072786_7_0_6; -.
DR   OMA; RESLQWV; -.
DR   OrthoDB; 1687028at2; -.
DR   Proteomes; UP000000537; Chromosome II.
DR   CollecTF; EXPREG_00000a50; -.
DR   GO; GO:0032993; C:protein-DNA complex; IMP:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IMP:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IMP:CollecTF.
DR   GO; GO:0008218; P:bioluminescence; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEP:CollecTF.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Luminescence; Quorum sensing; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..250
FT                   /note="Transcriptional activator protein LuxR"
FT                   /id="PRO_0000184162"
FT   DOMAIN          176..241
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        200..219
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   250 AA;  28520 MW;  42AC06375E28A34F CRC64;
     MNIKNINANE KIIDKIKTCN NNKDINQCLS EIAKIIHCEY YLFAIIYPHS IIKPDVSIID
     NYPEKWRKYY DDAGLLEYDP VVDYSKSHHS PINWNVFEKK TIKKESPNVI KEAQESGLIT
     GFSFPIHTAS NGFGMLSFAH SDKDIYTDSL FLHASTNVPL MLPSLVDNYQ KINTTRKKSD
     SILTKREKEC LAWASEGKST WDISKILGCS ERTVTFHLTN TQMKLNTTNR CQSISKAILT
     GAINCPYLKN