LUZP1_MOUSE
ID LUZP1_MOUSE Reviewed; 1068 AA.
AC Q8R4U7; A3KG96; Q3UV18; Q7TS71; Q8BQW1; Q99NG3; Q9CSL6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Leucine zipper protein 1;
DE AltName: Full=Leucine zipper motif-containing protein;
GN Name=Luzp1; Synonyms=Luzp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=8812416; DOI=10.1006/geno.1996.0425;
RA Sun D.-S., Chang A.C., Jenkins N.A., Gilbert D.J., Copeland N.G.,
RA Chang N.-C.A.;
RT "Identification, molecular characterization, and chromosomal localization
RT of the cDNA encoding a novel leucine zipper motif-containing protein.";
RL Genomics 36:54-62(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ; TISSUE=Peritoneal exudate;
RX PubMed=11702014; DOI=10.1159/000046172;
RA Lee M.W.-Y., Chang A.C., Sun D.-S., Hsu C.-Y., Chang N.-C.A.;
RT "Restricted expression of LUZP in neural lineage cells: a study in
RT embryonic stem cells.";
RL J. Biomed. Sci. 8:504-511(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-318 AND 661-1068.
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Embryo, and Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 522-1068.
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261 AND SER-660, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612 AND SER-660, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261; SER-612 AND SER-660, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus. Note=Also detected in soma and dendrites
CC of neurons. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the brain (at protein
CC level). {ECO:0000269|PubMed:8812416}.
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DR EMBL; L49344; AAA98795.1; -; mRNA.
DR EMBL; AF362727; AAM00269.1; -; Genomic_DNA.
DR EMBL; AL671173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK012514; BAB28289.1; -; mRNA.
DR EMBL; AK046323; BAC32681.2; ALT_SEQ; mRNA.
DR EMBL; AK137669; BAE23455.1; -; mRNA.
DR EMBL; BC053451; AAH53451.1; -; mRNA.
DR CCDS; CCDS38923.1; -.
DR RefSeq; NP_077772.2; NM_024452.2.
DR RefSeq; XP_006538984.1; XM_006538921.1.
DR AlphaFoldDB; Q8R4U7; -.
DR SMR; Q8R4U7; -.
DR BioGRID; 234675; 10.
DR IntAct; Q8R4U7; 6.
DR MINT; Q8R4U7; -.
DR STRING; 10090.ENSMUSP00000130758; -.
DR iPTMnet; Q8R4U7; -.
DR PhosphoSitePlus; Q8R4U7; -.
DR EPD; Q8R4U7; -.
DR jPOST; Q8R4U7; -.
DR MaxQB; Q8R4U7; -.
DR PaxDb; Q8R4U7; -.
DR PeptideAtlas; Q8R4U7; -.
DR PRIDE; Q8R4U7; -.
DR ProteomicsDB; 292052; -.
DR Antibodypedia; 30121; 111 antibodies from 23 providers.
DR Ensembl; ENSMUST00000001116; ENSMUSP00000001116; ENSMUSG00000001089.
DR Ensembl; ENSMUST00000063021; ENSMUSP00000060619; ENSMUSG00000001089.
DR Ensembl; ENSMUST00000105849; ENSMUSP00000101475; ENSMUSG00000001089.
DR Ensembl; ENSMUST00000170102; ENSMUSP00000130758; ENSMUSG00000001089.
DR GeneID; 269593; -.
DR KEGG; mmu:269593; -.
DR UCSC; uc008vie.1; mouse.
DR CTD; 7798; -.
DR MGI; MGI:107629; Luzp1.
DR VEuPathDB; HostDB:ENSMUSG00000001089; -.
DR eggNOG; ENOG502QV81; Eukaryota.
DR GeneTree; ENSGT00950000182852; -.
DR HOGENOM; CLU_010207_1_0_1; -.
DR InParanoid; Q8R4U7; -.
DR OMA; NHSAGTE; -.
DR OrthoDB; 176494at2759; -.
DR PhylomeDB; Q8R4U7; -.
DR TreeFam; TF331399; -.
DR BioGRID-ORCS; 269593; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Luzp1; mouse.
DR PRO; PR:Q8R4U7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8R4U7; protein.
DR Bgee; ENSMUSG00000001089; Expressed in placenta labyrinth and 249 other tissues.
DR ExpressionAtlas; Q8R4U7; baseline and differential.
DR Genevisible; Q8R4U7; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0060840; P:artery development; IMP:MGI.
DR GO; GO:0021503; P:neural fold bending; IMP:MGI.
DR GO; GO:0003281; P:ventricular septum development; IMP:MGI.
DR InterPro; IPR026734; Luzp1.
DR PANTHER; PTHR23166:SF7; PTHR23166:SF7; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Nucleus; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT CHAIN 2..1068
FT /note="Leucine zipper protein 1"
FT /id="PRO_0000234551"
FT REGION 251..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 11..354
FT /evidence="ECO:0000255"
FT COMPBIAS 256..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 256
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 261
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16452087,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 395
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 513
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 571
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 575
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 612
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 660
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:16452087,
FT ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19131326,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 680
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 691
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 746
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 906
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 952
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT MOD_RES 988
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86V48"
FT CONFLICT 371
FT /note="R -> S (in Ref. 2; AAM00269)"
FT /evidence="ECO:0000305"
FT CONFLICT 499
FT /note="S -> N (in Ref. 1; AAA98795)"
FT /evidence="ECO:0000305"
FT CONFLICT 594
FT /note="N -> D (in Ref. 1; AAA98795)"
FT /evidence="ECO:0000305"
FT CONFLICT 906
FT /note="S -> SASSEV (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 925..930
FT /note="Missing (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 935
FT /note="G -> R (in Ref. 1; AAA98795, 2; AAM00269 and 4;
FT AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 950..951
FT /note="PC -> SP (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 956
FT /note="E -> R (in Ref. 2; AAM00269)"
FT /evidence="ECO:0000305"
FT CONFLICT 958
FT /note="E -> R (in Ref. 2; AAM00269)"
FT /evidence="ECO:0000305"
FT CONFLICT 963
FT /note="Q -> H (in Ref. 1; AAA98795, 2; AAM00269 and 4;
FT AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 971
FT /note="R -> K (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 974
FT /note="N -> S (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 981
FT /note="L -> R (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 983
FT /note="P -> S (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
FT CONFLICT 1011
FT /note="C -> W (in Ref. 1; AAA98795 and 4; AAH53451)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1068 AA; 119311 MW; 26D88114F44B788C CRC64;
MAELTNYKDA ASNRHLRFKL QSLSRRLDEL EEATKNLQRA EDELLDLQDK VIQAEGSDSS
TLAEIEVLRQ RVLKIEGKDE EIKRAEDLCH TMKEKLEEEE NLTRELKSEI ERLQKRMVDL
EKLEEALSRS KNECSQLCLS LNEERNLTKK ISSELEMLRV KVKELESSED RLDKTEQSLV
SELEKLKSLT LSFVNERKYL NEKEKENEKI IKELTQKLEQ NKKMNRDHMR NASTFLERND
LRIEDGISST LSSKESKRKG SLDYLKQVEN ETRDKSENEK NRNQEDNKVK DLNQEIEKLK
TQIKHFESLE EELKKMRAKN NDLQDNYLTE LNRNRSLASQ LEEIKLQVRK QKELGNGDIE
GEDAFLLGRG RHERTKLKGH GSEASVSKHT SRELSPQHKR ERLRNREFAL SNEHYSLSSK
QASSPVFTNK RAAKASNMGM GTDSGTQETK RTEDRFAPGS SHSEGKRGRE QPSVLSRYPP
AAQEHTKVWK GAPKPGTESG LKGKVEKTTR TFSDSTHVSV PNDIVGKGDK TSDLSSEAHC
GKRGQVPGHA SQGTQAVESS CSKAIGALSS SQKASSEGLS KGKKTANGLA ADANFSNSKA
PILSKYPYSS RSQENILQGF SLPNKEGVDQ PVAVVMEDSS QHEALRCRVI KSSGREKPDS
DDDLDIESFV TAKLVNTTIT PEPEPKPQPN SREKVKSRGG TRTALFENDK NAAIENDSVK
PTRPSSNAIE FPDANCAGVK NQRPFSPREA LRSRAIIKPV IIDKDVKKIM GGSGTEVVLE
KQKSTSKSVT SKVTSSITIY PSDSSGPRAV PSEAPRERHT STSNIQVGPP ELTAISNHVS
SPLELSIHKH DITLQLTEAE RVGDGSPKNR AEMVVSRSSI LIKPSESVEK NSHVPPAETI
RWKSHSASSD SRHITVRNAW KSKRDLKCSE DPPTGIGRNM EATNAYTQRP CTDFLELEQP
RSQPSEQGAR RVGNSGDAPE LSPRRTQSSL TASEVLTRRD RMGGAITAAS CNHSSSMEEG
EDSTFVTSRR IHNPLEHSEL PGKQGLPEPE PVWTEERLHP AKPYAEED
